{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:03:02Z","timestamp":1761580982641},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T00:00:00Z","timestamp":1339027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>The physiological mechanisms contributing to sex differences following myocardial infarction (MI) are poorly understood. Given the strong relationship between sympathetic nerve activity (SNA) and outcome, we hypothesized there may be a sex difference in SNA responses to MI. In anaesthetized, open\u2010chest male, female and ovariectomized (OVX) female Wistar rats, mean arterial pressure, heart rate and renal SNA were recorded in response to ligation of the left coronary artery. In males, renal SNA increased by 30 \u00b1 6% in the first minute of coronary occlusion (<jats:italic>P<\/jats:italic> &lt; 0.05) and remained elevated at 18 \u00b1 7% above baseline (<jats:italic>P<\/jats:italic> &lt; 0.05) at 2 h following MI. In response to MI, ovary\u2010intact females displayed no change in renal SNA, whereas OVX females displayed a significant increase, similar to that seen in the males (increases of 43 \u00b1 11% at 1 min and 21 \u00b1 7% at 2 h post\u2010MI, <jats:italic>P<\/jats:italic> &lt; 0.05 <jats:italic>versus<\/jats:italic> intact females). Arterial baroreflex control of renal SNA had a smaller range in females (ovary intact and OVX) than males; no changes in arterial baroreflex responses were observed 1 h post\u2010MI in males or females. Denervating the arterial baroreceptors abolished the renal SNA response to MI in the males, whereas in ovary\u2010intact females and OVX females the response was unaltered. These findings suggest that ovarian hormones are able to blunt the initial sympathetic activation post\u2010MI in females and that the importance of the arterial baroreflex in mediating initial sympathetic activation post\u2010MI is different between the sexes.<\/jats:p>","DOI":"10.1113\/expphysiol.2012.065615","type":"journal-article","created":{"date-parts":[[2012,5,5]],"date-time":"2012-05-05T12:27:51Z","timestamp":1336220871000},"page":"1040-1053","source":"Crossref","is-referenced-by-count":6,"title":["Effects of sex and ovarian hormones on the initial renal sympathetic nerve activity response to myocardial infarction"],"prefix":"10.1113","volume":"97","author":[{"given":"Maximilian I.","family":"Pinkham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah\u2010Jane","family":"Guild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon 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