{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:36:37Z","timestamp":1773322597088,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T00:00:00Z","timestamp":1338422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>In this paper, we demonstrate that circulating antibodies from chronic periodontitis patients reacting with atrial \u03b2<jats:sub>1<\/jats:sub>\u2010adrenoceptors (\u03b2<jats:sub>1<\/jats:sub>\u2010ARs) act as an inducer of soluble CD40 ligand (sCD40L) release and prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) generation. By enzyme\u2010linked immunosorbent assay using \u03b2<jats:sub>1<\/jats:sub> synthetic peptide (with an amino acid sequence identical to the second loop of human myocardial \u03b2<jats:sub>1<\/jats:sub>\u2010ARs) as a coating antigen, we demonstrated reactivity against the second extracellular loop on human myocardial \u03b2<jats:sub>1<\/jats:sub>\u2010ARs. This autoantibody present in the serum of chronic periodontitis patients was significantly correlated with the release of sCD40L and PGE<jats:sub>2<\/jats:sub>. The release of sCD40L was blunted by atenolol, SP600125 and \u03b2<jats:sub>1<\/jats:sub> synthetic peptide, and PGE<jats:sub>2<\/jats:sub> generation was inhibited by DuP 697 and slightly by FR122049. The effects of the antibody incubated with isolated rat atria upregulated sCD40L release with an increase of PGE<jats:sub>2<\/jats:sub> production and c\u2010Jun N\u2010terminal kinase phosphorylation. These results indicate that in chronic periodontitis patients, there is a positive association between sCD40L release and PGE<jats:sub>2<\/jats:sub> generation via the action of \u03b2<jats:sub>1<\/jats:sub>\u2010AR antibodies.<\/jats:p>","DOI":"10.1113\/expphysiol.2012.065748","type":"journal-article","created":{"date-parts":[[2012,4,21]],"date-time":"2012-04-21T06:24:23Z","timestamp":1334989463000},"page":"1030-1039","source":"Crossref","is-referenced-by-count":4,"title":["\u03b2<sub>1<\/sub>\u2010Adrenoceptor antibody\u2010induced increase in soluble CD40 ligand release in chronic periodontitis patients: role of prostaglandin 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