{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:43:05Z","timestamp":1790678585283,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T00:00:00Z","timestamp":1382313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>New findings<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"explicit-label\">\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:bold>What is the central question of this study?<\/jats:bold>\n                        <\/jats:p>\n                        <jats:p>\n                          Inspiratory muscle fatigue (IMF) limits exercise performance and can augment ventilatory drive, which could\n                          <jats:italic>per se<\/jats:italic>\n                          impair performance due to greater respiratory muscle work. Using magnetic nerve stimulation to assess fatigue, we tested whether the IMF\u2010induced decrease in exercise performance results from increased respiratory muscle work alone and\/or a metaboreflex\u2010mediated increase in quadriceps muscle fatigue.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:bold>What is the main finding and its importance?<\/jats:bold>\n                        <\/jats:p>\n                        <jats:p>We found that IMF increased quadriceps muscle fatigue and perception of exertion and reduced performance in face of similar respiratory muscle work. This impairment is likely to result from increased metaboreflex activation. These findings support a reduction in metaboreflex as the mechanism leading to improved performance after respiratory muscle training.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>\n                  <jats:p>\n                    Inspiratory muscle fatigue (IMF) is suggested to compromise exercise performance, possibly via a respiratory muscle metaboreflex that impairs blood flow to working muscles, thereby accelerating the development of fatigue in these muscles. Cycling with IMF has also been associated with an excess ventilatory response, which could\n                    <jats:italic>per se<\/jats:italic>\n                    impair performance. Therefore, the present study investigated whether prior\u2010induced IMF would affect subsequent cycling performance via increased quadriceps muscle fatigue alone and whether fatigue\u2010induced excess ventilation would contribute to this impairment. Fourteen healthy male subjects (peak oxygen uptake, 57.0 \u00b1 5.5 ml min\n                    <jats:sup>\u22121<\/jats:sup>\n                    kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) cycled to exhaustion at 85% of their maximal work output with prior\u2010induced IMF (PF\u2010EX) and without prior\u2010induced IMF (C\u2010EX). Subjects then cycled twice for the duration of PF\u2010EX but without prior IMF, once with spontaneous breathing (C\u2010ISO) and once with breathing coached to match PF\u2010EX ventilation (MATCH\u2010ISO). Inspiratory muscle (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>tw<\/jats:sub>\n                    ) and quadriceps muscle contractility (\n                    <jats:italic>Q<\/jats:italic>\n                    <jats:sub>tw<\/jats:sub>\n                    ) was assessed via magnetic nerve stimulation before and after exercise. The time to exhaustion in the PF\u2010EX conditions was significantly reduced by 14% compared with C\u2010EX. The reduction in\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>tw<\/jats:sub>\n                    and\n                    <jats:italic>Q<\/jats:italic>\n                    <jats:sub>tw<\/jats:sub>\n                    was greater after PF\u2010EX (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>tw<\/jats:sub>\n                    , 17.3 \u00b1 9.7%;\n                    <jats:italic>Q<\/jats:italic>\n                    <jats:sub>tw<\/jats:sub>\n                    , 32.0 \u00b1 10.8%) than after MATCH\u2010ISO (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>tw<\/jats:sub>\n                    , 10.8 \u00b1 10.3%;\n                    <jats:italic>Q<\/jats:italic>\n                    <jats:sub>tw<\/jats:sub>\n                    , 23.3 \u00b1 15.2%;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05), which may explain the increased perception of exertion and earlier task failure with prior\u2010induced IMF. The augmented ventilatory drive had no effect on reductions in\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>tw<\/jats:sub>\n                    and\n                    <jats:italic>Q<\/jats:italic>\n                    <jats:sub>tw<\/jats:sub>\n                    after MATCH\u2010ISO compared with C\u2010ISO. Thus, prior\u2010induced IMF reduces exercise performance, probably as a result of the increased quadriceps muscle fatigue and thus greater perception of exertion independent of the excess respiratory drive when cycling with fatigued inspiratory muscles.\n                  <\/jats:p>","DOI":"10.1113\/expphysiol.2013.073635","type":"journal-article","created":{"date-parts":[[2013,9,7]],"date-time":"2013-09-07T01:29:02Z","timestamp":1378517342000},"page":"1705-1717","source":"Crossref","is-referenced-by-count":37,"title":["Effect of inspiratory muscle fatigue on exercise performance taking into account the fatigue\u2010induced excess respiratory drive"],"prefix":"10.1113","volume":"98","author":[{"given":"Thomas U.","family":"W\u00fcthrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic A.","family":"Notter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina 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