{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:36:52Z","timestamp":1773419812887,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T00:00:00Z","timestamp":1389312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["DK07352"],"award-info":[{"award-number":["DK07352"]}]},{"name":"NIH","award":["NS32352"],"award-info":[{"award-number":["NS32352"]}]},{"name":"NIH","award":["T32 DK07352"],"award-info":[{"award-number":["T32 DK07352"]}]},{"name":"NIH","award":["F32 DK84624"],"award-info":[{"award-number":["F32 DK84624"]}]},{"name":"NIH","award":["1 UL1 RR024150"],"award-info":[{"award-number":["1 UL1 RR024150"]}]},{"name":"NIH","award":["DK29953"],"award-info":[{"award-number":["DK29953"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Activation of the carotid body chemoreceptors with hypoxia alters baroreceptor\u2010mediated responses in humans. We aimed to examine whether this relationship can be translated to other chemoreceptor stimuli (i.e. hypoglycaemia).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>We show that hypoglycaemia\u2010mediated changes in heart rate variability and baroreflex sensitivity cannot be attributed exclusively to the carotid chemoreceptors; however, the chemoreceptors play a role in resetting the baroreflex working range during hypoglycaemia. These results provide a potential mechanism for impaired glycaemic control and increased risk of cardiac arrhythmias in patients with carotid chemoreceptor overactivity (i.e. sleep apnoea).<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Activation of the carotid body chemoreceptors with hypoxia alters baroreceptor\u2010mediated responses. We aimed to examine whether this relationship can be translated to other chemoreceptor stimuli (i.e. hypoglycaemia) by testing the following hypotheses: (i)\u00a0activation of the carotid body chemoreceptors with hypoglycaemia would reduce spontaneous cardiac baroreflex sensitivity (sCBRS) in healthy humans; and (ii)\u00a0desensitization of the carotid chemoreceptors with hyperoxia would restore sCBRS to baseline levels during hypoglycaemia. Ten young healthy adults completed two 180\u00a0min hyperinsulinaemic [2\u00a0mU\u00a0(kg\u00a0fat\u2010free mass)<jats:sup>\u22121<\/jats:sup>\u00a0min<jats:sup>\u22121<\/jats:sup>], hypoglycaemic (\u223c3.2\u00a0\u03bcmol\u00a0ml<jats:sup>\u22121<\/jats:sup>) clamps, separated by at least 1\u00a0week and randomized to normoxia (arterial partial pressure of O<jats:sub>2<\/jats:sub>, 122\u00a0\u00b1\u00a010\u00a0mmHg) or hyperoxia (arterial partial pressure of O<jats:sub>2<\/jats:sub>, 424\u00a0\u00b1\u00a0123\u00a0mmHg; to blunt activation of the carotid body glomus cells). Changes in heart rate, blood pressure, plasma catecholamines, heart rate variability (HRV) and sCBRS were assessed. During hypoglycaemia, HRV and sCBRS were reduced (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and the baroreflex working range was shifted to higher heart rates. When hyperoxia was superimposed on hypoglycaemia, there was a greater reduction in blood pressure and a blunted rise in heart rate when compared with normoxic conditions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05); however, there was no detectable effect of hyperoxia on sCBRS or HRV during hypoglycaemia (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). In summary, hypoglycaemia\u2010mediated changes in HRV and sCBRS cannot be attributed exclusively to the carotid chemoreceptors; however, the chemoreceptors appear to play a role in resetting the baroreflex working range during hypoglycaemia.<\/jats:p><\/jats:sec>","DOI":"10.1113\/expphysiol.2013.076869","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T04:10:49Z","timestamp":1389413449000},"page":"640-650","source":"Crossref","is-referenced-by-count":19,"title":["Role of the carotid body chemoreceptors in baroreflex control of blood pressure during hypoglycaemia in humans"],"prefix":"10.1113","volume":"99","author":[{"given":"Jacqueline K.","family":"Limberg","sequence":"first","affiliation":[{"name":"Departments of Anesthesiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Departments of 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