{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:04:52Z","timestamp":1767855892090,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\"><jats:list-item><jats:p><jats:bold>What is the topic of this review?<\/jats:bold><\/jats:p><jats:p>Myometrial quiescence is a highly regulated process, in which pregnant myometrium remains completely relaxed, overcoming its inherent tendency to contract. The maintenance of myometrial quiescence is a key step in controlling the duration of pregnancy. Currently, the mechanisms underlying myometrial quiescence of pregnancy are not fully known.<\/jats:p><\/jats:list-item><jats:list-item><jats:p><jats:bold>What advances does it highlight?<\/jats:bold><\/jats:p><jats:p>Brain natriuretic peptide is produced by the fetal membranes (chorion and amnion) and acts in a paracrine fashion. Brain natriuretic peptide plays a key role in maintaining myometrial quiescence. A premature decrease in production of brain natriuretic peptide may lead to preterm labour.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Myometrial quiescence is a physiological stage of the myometrium during pregnancy. It is a period of active relaxation of the myometrial smooth muscle cells; myometrial quiescence is responsible for maintaining pregnancy. The precise mechanisms underlying myometrial quiescence have not been completely elucidated, although many mediators and cellular pathways have been described as playing a role. Fetal membranes (chorion and amnion) produce and release one or more substances that inhibit myometrial contractions, playing a central role in the maintenance of myometrial quiescence. Brain natriuretic peptide (BNP) is more potent than any other natriuretic peptide in inhibiting myometrial contractions<jats:italic>in vitro<\/jats:italic>. Brain natriuretic peptide is produced by the chorion and amnion, mainly during myometrial quiescence, and decreasing towards the end of pregnancy. Production of BNP is reduced in fetal membranes obtained from women in preterm labour. It is postulated that BNP, acting in a paracrine fashion, plays a key role in the maintaining myometrial quiescence and, therefore, controlling the duration of pregnancy. Furthermore, it is postulated that a premature decrease of BNP production by the fetal membranes may cause preterm labour and preterm birth.<\/jats:p><\/jats:sec>","DOI":"10.1113\/expphysiol.2013.077446","type":"journal-article","created":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T01:16:29Z","timestamp":1390007789000},"page":"489-494","source":"Crossref","is-referenced-by-count":9,"title":["The role of brain natriuretic peptide in maintaining myometrial quiescence during pregnancy"],"prefix":"10.1113","volume":"99","author":[{"given":"Jorge A.","family":"Carvajal","sequence":"first","affiliation":[{"name":"Unidad de Medicina Materno Fetal Divisi\u00f3n de Obstetricia y Ginecolog\u00eda Escuela de Medicina Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,4]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"crossref","first-page":"8566","DOI":"10.1016\/S0021-9258(19)38925-2","article-title":"Ring\u2010deleted analogs of atrial natriuretic factor inhibit adenylate cyclase\/cAMP system. 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