{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:30:58Z","timestamp":1789965058170,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n                    <jats:title>New Findings<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>What is the topic of this review?<\/jats:p>\n                          <jats:p>This article describes the contribution of oxidative stress and pro\u2010inflammatory cytokines to the enhanced carotid body chemosensory responsiveness to the hypoxia and systemic hypertension induced by chronic intermittent hypoxia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>What advances does it highlight?<\/jats:p>\n                          <jats:p>Chronic intermittent hypoxia enhances the carotid body chemosensory discharge during normoxia and hypoxia, leading to sympathetic overactivity and hypertension. New evidence suggests that chronic intermittent hypoxia increases pro\u2010inflammatory cytokines. Here, we discuss the role of inflammation in the alterations of the carotid chemoreceptor function as well as the cardiorespiratory alterations following chronic intermittent hypoxia.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Chronic intermittent hypoxia (CIH), the main characteristic of obstructive sleep apnoea, enhances carotid body (CB) chemosensory discharges during normoxia and hypoxia and elicits hypertension. These alterations are attributed to oxidative stress, because antioxidants prevent the enhanced CB chemosensory discharges and the hypertension. In this report, we discuss new evidence supporting the suggestion that oxidative stress\u2010induced upregulation of pro\u2010inflammatory cytokines (i.e. tumour necrosis factor\u2010\u03b1 and interleukin\u20101\u03b2) in the CB is involved in the chemosensory potentiation and the hypertension following CIH. Anti\u2010inflammatory treatment with ibuprofen prevents the increased tumour necrosis factor\u2010\u03b1 and interleukin\u20101\u03b2 levels in the CB and the hypertension, but does not reduce the enhanced chemosensory hypoxic response and the local oxidative stress in the CB. In contrast, antioxidant treatment with ascorbic acid prevents the increase in cytokine concentrations and CB oxidative stress, the chemosensory potentiation and the hypertension. Thus, the enhanced CB chemosensory responses to hypoxia depend critically on the oxidative stress, but not on the increased tumour necrosis factor\u2010\u03b1 and interleukin\u20101\u03b2 in the CB. We discuss a possible role for pro\u2010inflammatory cytokines in development of the hypertension produced by CIH, acting on cardiorespiratory centres located in the CNS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/expphysiol.2014.079525","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T02:05:20Z","timestamp":1418695520000},"page":"149-155","source":"Crossref","is-referenced-by-count":54,"title":["Inflammation and oxidative stress during intermittent hypoxia: the impact on chemoreception"],"prefix":"10.1113","volume":"100","author":[{"given":"Rodrigo","family":"Iturriaga","sequence":"first","affiliation":[{"name":"Laboratorio de Neurobiolog\u00eda Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban A.","family":"Moya","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurobiolog\u00eda Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Del Rio","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurobiolog\u00eda Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica Universidad Aut\u00f3noma de Chile  Santiago 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