{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:00:20Z","timestamp":1791273620836,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T00:00:00Z","timestamp":1410307200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the topic of this review?<\/jats:bold><\/jats:p>\n<jats:p>This review documents a metabolic role of insulin action in brain.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What advances does it highlight?<\/jats:bold><\/jats:p>\n<jats:p>This review highlights the role of insulin signalling in the hypothalamus and dorsal vagal complex in the regulation of hepatic glucose production and food intake.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Insulin resistance is a hallmark feature of type\u00a02 diabetes and obesity. In addition to the classical view that insulin resistance in the liver, muscle and fat disrupts glucose homeostasis, studies in the past decade have illustrated that insulin resistance in the hypothalamus dysregulates hepatic glucose production and food intake, leading to type\u00a02 diabetes and obesity. This invited review argues that in addition to the hypothalamus, insulin signalling in the dorsal vagal complex regulates hepatic glucose production and food intake. A thorough understanding of the physiological and pathophysiological mechanisms of insulin action in the hypothalamus and dorsal vagal complex is necessary in order to identify therapeutic targets for obesity and type\u00a02 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1113\/expphysiol.2014.079962","type":"journal-article","created":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T04:42:35Z","timestamp":1403930555000},"page":"1104-1109","source":"Crossref","is-referenced-by-count":39,"title":["Insulin action in the hypothalamus and dorsal vagal complex"],"prefix":"10.1113","volume":"99","author":[{"given":"Mona A.","family":"Abraham","sequence":"first","affiliation":[{"name":"Toronto General Research Institute and Department of Medicine University Health Network  Toronto Ontario Canada"},{"name":"Department of Physiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice M.","family":"Filippi","sequence":"additional","affiliation":[{"name":"Toronto General Research Institute and Department of Medicine University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil Myoung","family":"Kang","sequence":"additional","affiliation":[{"name":"Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Seon","family":"Kim","sequence":"additional","affiliation":[{"name":"Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony K. 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