{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:46:34Z","timestamp":1770482794423,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p><jats:bold>What is the topic of this review?<\/jats:bold><\/jats:p>\n<jats:p>The major topic of this review addresses the effects of mesenchymal stem cell treatment in renovascular hypertension.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p><jats:bold>What advances does it highlight?<\/jats:bold><\/jats:p>\n<jats:p>This therapy may be a promising strategy to treat renovascular hypertension and its renal consequences in the near future.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Renovascular hypertension induced by the two\u2010kidney, one\u2010clip technique is a renin\u2013angiotensin system\u2010dependent model that leads to renal vascular rarefaction, fibrosis and renal failure. Treatment of renovascular hypertension remains a challenge, and thus, new therapies are needed. In this report, we discuss the beneficial effects of mesenchymal stem cells on the reconstruction of the renal parenchyma of the stenotic kidney to improve vascular rarefaction and fibrosis. Mesenchymal stem cell therapy prevented the progressive increase in systolic arterial pressure, reduced sympathetic hyperactivity, improved renal morphology, induced neovascularization and reduced fibrosis in stenotic kidneys. Although this therapy may be a promising strategy to treat renovascular hypertension and its renal consequences, further studies are necessary to improve the efficiency of mesenchymal stem cells.<\/jats:p><\/jats:sec>","DOI":"10.1113\/expphysiol.2014.080531","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T08:32:00Z","timestamp":1421829120000},"page":"491-495","source":"Crossref","is-referenced-by-count":8,"title":["Effects of mesenchymal stem cells in renovascular hypertension"],"prefix":"10.1113","volume":"100","author":[{"given":"Elizabeth B.","family":"Oliveira\u2010Sales","sequence":"first","affiliation":[{"name":"Department of Medicine Renal Division Federal University of Sao Paulo  Sao Paulo Brazil"},{"name":"Department of Physiology Cardiovascular Division Federal University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa A.","family":"Varela","sequence":"additional","affiliation":[{"name":"Department of Medicine Renal Division Federal University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassia T.","family":"Bergamaschi","sequence":"additional","affiliation":[{"name":"Department of Physiology Cardiovascular Division Federal University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruy R.","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Physiology Cardiovascular Division Federal University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirian A.","family":"Boim","sequence":"additional","affiliation":[{"name":"Department of Medicine Renal Division Federal University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,25]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000077477.40824.52"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.788653"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5680fje"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.426"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2013.03.002"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.64"},{"key":"e_1_2_2_8_1","article-title":"Intra\u2010renal delivery of mesenchymal stem cells and endothelial progenitor cells attenuates hypertensive cardiomyopathy in experimental renovascular hypertension","author":"Eirin A","year":"2014","journal-title":"Cell Transplant"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1047"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363680"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.08.022"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.176826"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.59.3.347"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-014-1199-1"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.59.061506.154239"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00870"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31822dc5d3"},{"key":"e_1_2_2_18_1","first-page":"170","article-title":"Unraveling the mystery of Goldblatt hypertension","volume":"13","author":"Navar LG","year":"1998","journal-title":"News Physiol Sci"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.150425"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2007.12"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078464"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.17"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.02.001"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090504"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00240-2"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044092"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.633"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220902928981"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2012.0266"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.11.003"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1263"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2014.080531","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.2014.080531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T17:58:55Z","timestamp":1696183135000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.2014.080531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,25]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1113\/expphysiol.2014.080531"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.2014.080531","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,25]]}}}