{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:40:00Z","timestamp":1789861200718,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:00:00Z","timestamp":1418083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Previous studies have shown that hypersympathetic nerve activity results in ventricular electrophysiological changes and facilitates the occurrence of ventricular arrhythmias. Vagus nerve stimulation has shown therapeutic potential for myocardial infarction\u2010induced ventricular arrhythmias. However, the actions of vagus nerve stimulation on hypersympathetic nerve activity\u2010induced ventricular electrophysiological changes are still unknown.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>We show that vagus nerve stimulation is able to reverse hypersympathetic nerve activity\u2010induced ventricular electrophysiological changes and suppress the occurrence of ventricular fibrillation. These findings further suggest that vagus nerve stimulation may be an effective treatment option for ventricular arrhythmias, especially in patients with myocardial infarction or heart failure.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Vagus nerve stimulation (VNS) has shown therapeutic potential for myocardial infarction\u2010induced ventricular arrhythmias. This study aimed to investigate the effects of VNS on ventricular electrophysiological changes induced by hypersympathetic nerve activity. Seventeen open\u2010chest dogs were subjected to left stellate ganglion stimulation (LSGS) for 4\u00a0h to simulate hypersympathetic tone. All animals were randomly assigned to the VNS group (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) or the control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a08). In the VNS group, VNS was performed at the voltage causing a 10% decrease in heart rate for hours\u00a03\u20134 during 4\u00a0h of LSGS. During the first 2\u00a0h of LSGS, the ventricular effective refractory period (ERP) and action potential duration (APD) were both progressively and significantly decreased; the spatial dispersion of ERP, maximal slope of the restitution curve and pacing cycle length of APD alternans were all increased. With LSGS\u00a0+\u00a0VNS during the next 2\u00a0h, there was a significant return of all the altered electrophysiological parameters towards baseline levels. In the eight control dogs that received 4\u00a0h of LSGS without VNS, all the parameters changed progressively, but without any reversals. The ventricular fibrillation threshold was higher in the VNS group than in the control group (17.3\u00a0\u00b1\u00a03.4 <jats:italic>versus<\/jats:italic> 11.3\u00a0\u00b1\u00a03.8\u00a0V, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The present study demonstrated that VNS was able to reverse LSGS\u2010induced ventricular electrophysiological changes and suppress the occurrence of ventricular fibrillation.<\/jats:p><\/jats:sec>","DOI":"10.1113\/expphysiol.2014.082842","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T05:24:19Z","timestamp":1415424259000},"page":"239-248","source":"Crossref","is-referenced-by-count":23,"title":["Vagus nerve stimulation reverses ventricular electrophysiological changes induced by hypersympathetic nerve activity"],"prefix":"10.1113","volume":"100","author":[{"given":"Jie","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Suizhou Hospital Hubei University of Medicine  Suizhou City Hubei Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Suizhou Hospital Hubei University of Medicine  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