{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:13:00Z","timestamp":1790705580403,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T00:00:00Z","timestamp":1423440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Recently, the heterogeneity of the cerebral arterial circulation has been argued. Orthostatic tolerance may be associated with an orthostatic stress\u2010induced change in blood flow in vertebral arteries rather than in internal carotid arteries, because vertebral arteries supply blood to the medulla oblongata, which is the location of important cardiac, vasomotor and respiratory control centres.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>The effect of graded orthostatic stress on vertebral artery blood flow is different from that on internal carotid artery blood flow. This response allows for the possibility that orthostatic tolerance may be associated with haemodynamic changes in posterior rather than anterior cerebral blood flow.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Recently, the heterogeneity of the cerebral arterial circulation has been argued, but the characteristics of vertebral artery (VA) and internal carotid artery (ICA) blood flow during graded orthostatic stress remain unknown. We hypothesized that the change in blood flow in VA is not similar to that in ICA blood flow during graded orthostatic stress. We measured blood flows in both ICA and VA during graded lower body negative pressure (LBNP; \u221220, \u221235\u00a0and \u221250\u00a0mmHg) by using two colour\u2010coded ultrasound systems. The effect of graded orthostatic stress on the VA blood flow was different from that on the ICA blood flow (LBNP\u00a0\u00d7\u00a0artery, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.006). The change in ICA blood flow was associated with the level of LBNP (<jats:italic>r<\/jats:italic> = 0.287, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.029), and a reduction in ICA blood flow from pre\u2010LBNP was observed during \u221250\u00a0mmHg LBNP (from 411\u00a0\u00b1\u00a035 to 311\u00a0\u00b1\u00a040\u00a0ml\u00a0min<jats:sup>\u22121<\/jats:sup>, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.044) without symptoms of presyncope. In contrast, VA blood flow was unchanged during graded LBNP compared with the baseline (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.597) relative to the reduction in ICA blood flow and thus there was no relationship between VA blood flow and the level of LBNP (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.167, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.219). These findings suggest that the change in ICA blood flow is due to the level of LBNP during graded orthostatic stress, but the change in VA blood flow is different from that in ICA blood flow across the different levels of LBNP. These findings provide the possibility that posterior cerebral blood flow decreases only during severe orthostatic stress and is therefore more likely to be linked with orthostatic tolerance.<\/jats:p><\/jats:sec>","DOI":"10.1113\/expphysiol.2014.083964","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T20:10:24Z","timestamp":1421179824000},"page":"259-266","source":"Crossref","is-referenced-by-count":60,"title":["Blood flow in internal carotid and vertebral arteries during graded lower body negative pressure in humans"],"prefix":"10.1113","volume":"100","author":[{"given":"Shigehiko","family":"Ogoh","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Toyo University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Sato","sequence":"additional","affiliation":[{"name":"Research Institute of Physical Fitness Japan Women's College of Physical Education  Tokyo 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