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These can be categorized into plasma membrane Cl<jats:sup>\u2212<\/jats:sup> channels and vesicular Cl<jats:sup>\u2212<\/jats:sup>\/H<jats:sup>+<\/jats:sup>\u2010exchangers. They are involved in the regulation of membrane excitability, transepithelial transport, extracellular ion homeostasis, endocytosis and lysosomal function. Diseases caused by CLC dysfunction include myotonia, neurodegeneration, deafness, blindness, leukodystrophy, male infertility, renal salt loss, kidney stones and osteopetrosis, revealing a surprisingly broad spectrum of biological roles for chloride transport that was unsuspected when I set out to clone the first voltage\u2010gated chloride channel.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp270043","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T17:23:43Z","timestamp":1421342623000},"page":"4091-4109","source":"Crossref","is-referenced-by-count":108,"title":["Discovery of CLC transport proteins: cloning, structure, function and pathophysiology"],"prefix":"10.1113","volume":"593","author":[{"given":"Thomas J.","family":"Jentsch","sequence":"first","affiliation":[{"name":"Leibniz\u2010Institut f\u00fcr Molekulare Pharmakologie (FMP) and Max\u2010Delbr\u00fcck\u2010Centrum f\u00fcr Molekulare Medizin (MDC)  Berlin 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