{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T02:52:12Z","timestamp":1769395932720,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T00:00:00Z","timestamp":1426723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL075283"],"award-info":[{"award-number":["HL075283"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Women with the postural orthostatic tachycardia syndrome (POTS) report fluctuations in orthostatic tolerance throughout the menstrual cycle.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The mechanism(s) underlying blood pressure control across the menstrual cycle in women with POTS are unknown.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The findings of the present study indicate that the menstrual cycle does not affect muscle sympathetic nerve activity but modulates blood pressure and vasoconstriction in POTS women during orthostatic stress.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Factors other than sympathetic neural activity are likely responsible for the symptoms of orthostatic intolerance across the menstrual cycle in women with POTS.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Patients with the postural orthostatic tachycardia syndrome (POTS) are primarily premenopausal women, which may be attributed to female sex hormones. We tested the hypothesis that hormonal fluctuations of the menstrual cycle alter sympathetic neural activity and orthostatic tolerance in POTS women. Ten POTS women were studied during the early follicular (EF) and mid\u2010luteal (ML) phases of the menstrual cycle. Haemodynamics and muscle sympathetic nerve activity (MSNA) were measured when supine, during 60\u00a0deg upright tilt for 45\u00a0min or until presyncope, and during the cold pressor test (CPT) and Valsalva manoeuvres. Blood pressure and total peripheral resistance were higher during rest and tilting in the ML than EF phase; however, heart rate, stroke volume and cardiac output were similar between phases. There were no mean\u00a0\u00b1\u00a0SD differences in MSNA burst frequency (8\u00a0\u00b1\u00a08 EF phase <jats:italic>vs<\/jats:italic>. 10\u00a0\u00b1\u00a010\u00a0bursts\u00a0min<jats:sup>\u20131<\/jats:sup> ML phase at rest; 34\u00a0\u00b1\u00a015\u00a0EF phase <jats:italic>vs<\/jats:italic>. 36\u00a0\u00b1\u00a016\u00a0bursts\u00a0min<jats:sup>\u20131<\/jats:sup> ML phase at 5\u00a0min tilt), burst incidence or total activity, nor any differences in the cardiovagal and sympathetic baroreflex sensitivities between phases under any condition. The incidence of presyncope was also the same between phases. There were no differences in haemodynamic or sympathetic responses to CPT or Valsalva. These results suggest that the menstrual cycle does not affect sympathetic neural activity but modulates blood pressure and vasoconstriction in POTS women during tilting. Thus, factors other than sympathetic neural activity are probably responsible for the symptoms of orthostatic intolerance across the menstrual cycle in women with POTS.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp270088","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T05:51:08Z","timestamp":1423201868000},"page":"2131-2143","source":"Crossref","is-referenced-by-count":17,"title":["Menstrual cycle phase does not affect sympathetic neural activity in women with postural orthostatic tachycardia syndrome"],"prefix":"10.1113","volume":"593","author":[{"given":"Abigail S.L.","family":"Stickford","sequence":"first","affiliation":[{"name":"Institute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital Dallas  Dallas TX USA"},{"name":"University of Texas Southwestern Medical Center  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany 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