{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:36:40Z","timestamp":1775677000337,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:00:00Z","timestamp":1434499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovation Fund Denmark","doi-asserted-by":"crossref","award":["0603-00381B"],"award-info":[{"award-number":["0603-00381B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Kathrine and Vigo Skovgaards foundation"},{"DOI":"10.13039\/501100004825","name":"Nordea Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004825","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Simon Fougner Hartmann Family Foundation"},{"name":"The Danish Ministry of Science, Technology and Innovation (via UNIK program: Food, Fitness & Pharma for Health and Disease)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2015,7,15]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Roux\u2010en\u2010Y gastric bypass surgery leads to remission of type 2 diabetes in the majority of patients suffering from the disease.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The gut hormone glucagon\u2010like peptide\u20101 is believed to be of major importance for the remission process.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The present project demonstrates a marked difference in the chance of remission of type 2 diabetes in patients with low or high preoperative \u03b2\u2010cell function in spite of a similar post\u2010surgery increase in postprandial glucagon\u2010like peptide\u20101 release.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Furthermore, post\u2010surgery intravenous glucose administration, which does not stimulate release of glucagon\u2010like peptide\u20101, leads to increased insulin secretion in the patients with the best preoperative \u03b2\u2010cell function.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Together the present findings indicate that patients with type 2 diabetes with high preoperative \u03b2\u2010cell function experience a glucagon\u2010like peptide\u20101\u2010independent increase in \u03b2\u2010cell function after gastric bypass surgery.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>The majority of the patients with type 2 diabetes (T2DM) show remission after Roux\u2010en\u2010Y gastric bypass (RYGB). This is the result of increased postoperative insulin sensitivity and \u03b2\u2010cell secretion. The aim of the present study was to elucidate the importance of the preoperative \u03b2\u2010cell function in T2DM for the chance of remission after RYGB. Fifteen patients with and 18 without T2DM had 25\u00a0g oral (OGTT) and intravenous (IVGTT) glucose tolerance tests performed at inclusion, after a diet\u2010induced weight loss, and 4 and 18\u00a0months after RYGB. Postoperative first phase insulin secretion rate (ISR) during the IVGTT and \u03b2\u2010cell glucose sensitivity during the OGTT increased in T2DM. Postoperative insulin sensitivity and the disposition index (DI) markedly increased in both groups. By stratifying the T2DM into two groups according to highest (T2DM<jats:sub>high<\/jats:sub>) and lowest (T2DM<jats:sub>low<\/jats:sub>) baseline DI, a restoration of first phase ISR and \u03b2\u2010cell glucose sensitivity were seen only in T2DM<jats:sub>high<\/jats:sub>. Remission of type 2 diabetes was 71 and 38% in T2DM<jats:sub>high<\/jats:sub> and T2DM<jats:sub>low<\/jats:sub>, respectively. Postoperative postprandial GLP\u20101 concentrations increased markedly, but did not differ between the groups. Our findings emphasize the importance of the preoperative of \u03b2\u2010cell function for remission of diabetes after RYGB.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp270264","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T10:22:57Z","timestamp":1428920577000},"page":"3123-3133","source":"Crossref","is-referenced-by-count":31,"title":["Preoperative \u03b2\u2010cell function in patients with type 2 diabetes is important for the outcome of Roux\u2010en\u2010Y gastric bypass surgery"],"prefix":"10.1113","volume":"593","author":[{"given":"Michael Taulo","family":"Lund","sequence":"first","affiliation":[{"name":"Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Blegdamsvej 3B Copenhagen Denmark"},{"name":"Department of Surgery Koege Hospital  Lykkebaekvej 1 4600 Koege 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