{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:24:46Z","timestamp":1791296686742,"version":"4.1.0"},"reference-count":106,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,5]],"date-time":"2015-07-05T00:00:00Z","timestamp":1436054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hessian Ministry of Higher Education, Research and the Arts","award":["III L 4-518\/17.004 (2013)"],"award-info":[{"award-number":["III L 4-518\/17.004 (2013)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2016,4,15]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>MicroRNAs (miRs) have emerged as potent regulators of pathways in physiological and disease contexts. This review focuses on the role of miRs in ageing of the cardiovascular system. Several miRs have been described to be regulated during ageing and some of these miRs are involved in the regulation of ageing\u2010related processes. We discuss the roles of miR\u201034, miR\u2010217 and miR\u201029, which are induced during ageing in the vasculature. The roles of miR\u201034, miR\u201029 (age\u2010induced) and miR\u201018\/19, which are decreased during ageing in the heart, are discussed as well. Furthermore, numerous miRs that play a role in diseases associated with ageing, like diabetes, atherosclerosis, hypertension, cardiac hypertrophy and atrial fibrillation, are also briefly discussed. miRs also serve as circulating biomarkers for cardiovascular ageing or ageing\u2010associated diseases. Finally, pharmacological modulation of ageing\u2010related miRs might become a promising strategy to combat cardiovascular ageing in a clinical setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp270557","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T02:05:45Z","timestamp":1433383545000},"page":"2085-2094","source":"Crossref","is-referenced-by-count":43,"title":["MicroRNAs in cardiovascular ageing"],"prefix":"10.1113","volume":"594","author":[{"given":"Timon","family":"Seeger","sequence":"first","affiliation":[{"name":"Department of Medicine (Division of Cardiology) Stanford Cardiovascular Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine  Stanford CA USA"},{"name":"Institute for Cardiovascular Regeneration Center of Molecular Medicine, Goethe University  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinier A.","family":"Boon","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Regeneration Center of Molecular Medicine, Goethe University  Frankfurt am Main Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site RheinMain  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,5]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.302400"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14281"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu180"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70577"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-011-0235-6"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.12.014"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206432109"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35053110"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1253"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.5167604"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.207"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11919"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.255737"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1582"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710228105"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013675"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1953310"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00307.2014"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2126"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.267732"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001207"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03049"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1256-3"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2866"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.08.009"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300144"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.226696"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140391"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.12.013"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000882"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.08.035"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-353"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.01.011"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03120"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.86"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3838"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1467506"},{"key":"e_1_2_2_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05939"},{"key":"e_1_2_2_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.56"},{"key":"e_1_2_2_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3318"},{"key":"e_1_2_2_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001904"},{"key":"e_1_2_2_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.300682"},{"key":"e_1_2_2_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2936"},{"key":"e_1_2_2_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062961"},{"key":"e_1_2_2_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.07.012"},{"key":"e_1_2_2_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209026"},{"key":"e_1_2_2_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-012-9407-9"},{"key":"e_1_2_2_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1181"},{"key":"e_1_2_2_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303425"},{"key":"e_1_2_2_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.304707"},{"key":"e_1_2_2_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178178"},{"key":"e_1_2_2_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065329"},{"key":"e_1_2_2_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90529-Y"},{"key":"e_1_2_2_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf476"},{"key":"e_1_2_2_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600385"},{"key":"e_1_2_2_58_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100371"},{"key":"e_1_2_2_59_1","doi-asserted-by":"publisher","DOI":"10.1155\/JBB\/2006\/26818"},{"key":"e_1_2_2_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.10.003"},{"key":"e_1_2_2_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.03.005"},{"key":"e_1_2_2_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102513"},{"key":"e_1_2_2_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.302929"},{"key":"e_1_2_2_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.958967"},{"key":"e_1_2_2_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090599"},{"key":"e_1_2_2_66_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI62185"},{"key":"e_1_2_2_67_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61598"},{"key":"e_1_2_2_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140917319"},{"key":"e_1_2_2_69_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.224238"},{"key":"e_1_2_2_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.864629"},{"key":"e_1_2_2_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2014.03.005"},{"key":"e_1_2_2_72_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.082610"},{"key":"e_1_2_2_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010724"},{"key":"e_1_2_2_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.92"},{"key":"e_1_2_2_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2012.09.004"},{"key":"e_1_2_2_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht149"},{"key":"e_1_2_2_77_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43604"},{"key":"e_1_2_2_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.092"},{"key":"e_1_2_2_79_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI62876"},{"key":"e_1_2_2_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2011.07.004"},{"key":"e_1_2_2_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.200451"},{"key":"e_1_2_2_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/35002607"},{"key":"e_1_2_2_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00015"},{"key":"e_1_2_2_84_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76069"},{"key":"e_1_2_2_85_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.14.76"},{"key":"e_1_2_2_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.38"},{"key":"e_1_2_2_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00759-1"},{"key":"e_1_2_2_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs184"},{"key":"e_1_2_2_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep00961"},{"key":"e_1_2_2_90_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110563"},{"key":"e_1_2_2_91_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.13.4436"},{"key":"e_1_2_2_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07511"},{"key":"e_1_2_2_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu184"},{"key":"e_1_2_2_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt042"},{"key":"e_1_2_2_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2011.00714.x"},{"key":"e_1_2_2_96_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.183426"},{"key":"e_1_2_2_97_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139089"},{"key":"e_1_2_2_98_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805038105"},{"key":"e_1_2_2_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2282"},{"key":"e_1_2_2_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.244"},{"key":"e_1_2_2_101_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096290"},{"key":"e_1_2_2_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12416"},{"key":"e_1_2_2_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq053"},{"key":"e_1_2_2_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep07425"},{"key":"e_1_2_2_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.056"},{"key":"e_1_2_2_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.05.047"},{"key":"e_1_2_2_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00186"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FJP270557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FJP270557","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP270557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:01:32Z","timestamp":1696150892000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP270557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,5]]},"references-count":106,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,4,15]]}},"alternative-id":["10.1113\/JP270557"],"URL":"https:\/\/doi.org\/10.1113\/jp270557","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,5]]}}}