{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:46:20Z","timestamp":1785242780187,"version":"3.55.0"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T00:00:00Z","timestamp":1436313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["12\/613"],"award-info":[{"award-number":["12\/613"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["14\/216"],"award-info":[{"award-number":["14\/216"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lottery Health Board of New Zealand","award":["Lotteries 353124"],"award-info":[{"award-number":["Lotteries 353124"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Magnesium sulphate is the recommended treatment for pre\u2010eclampsia and is now widely recommended for perinatal neuroprotection.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            MgSO\n                            <jats:sub>4<\/jats:sub>\n                            has vasodilatory and negative inotropic effects; however, it is unknown whether it impairs the cardiovascular and cerebrovascular adaptations to acute asphyxia in preterm fetuses.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Intravenous infusion of a clinically comparable dose of MgSO\n                            <jats:sub>4<\/jats:sub>\n                            to the preterm fetus was associated with no change in blood pressure, reduced fetal heart rate and increased femoral arterial conductance and blood flow; femoral arterial waveform height and width were increased, consistent with increased stroke volume during MgSO\n                            <jats:sub>4<\/jats:sub>\n                            infusion.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            During asphyxia MgSO\n                            <jats:sub>4<\/jats:sub>\n                            was associated with increased carotid and femoral arterial conductance and blood flows; after asphyxia, fetal heart rate was lower and carotid and femoral blood flows and vascular conductance were greater in MgSO\n                            <jats:sub>4<\/jats:sub>\n                            \u2010treated fetuses.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            These data demonstrate that MgSO\n                            <jats:sub>4<\/jats:sub>\n                            may increase perfusion of peripheral vascular beds during adverse perinatal events such as asphyxia.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Magnesium sulphate is a standard therapy for eclampsia in pregnancy and is widely recommended for perinatal neuroprotection during threatened preterm labour. MgSO\n                      <jats:sub>4<\/jats:sub>\n                      is a vasodilator and negative inotrope. Therefore the aim of this study was to investigate the effect of MgSO\n                      <jats:sub>4<\/jats:sub>\n                      on the cardiovascular and cerebrovascular responses of the preterm fetus to asphyxia. Fetal sheep were instrumented at 98\u00a0\u00b1\u00a01\u00a0days of gestation (term\u00a0=\u00a0147\u00a0days). At 104\u00a0days, unanaesthetised fetuses were randomly assigned to receive an intravenous infusion of MgSO\n                      <jats:sub>4<\/jats:sub>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06) or saline (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a09). At 105\u00a0days all fetuses underwent umbilical cord occlusion for 25\u00a0min. Before occlusion, MgSO\n                      <jats:sub>4<\/jats:sub>\n                      treatment reduced heart rate and increased femoral blood flow (FBF) and vascular conductance compared to controls. During occlusion, carotid and femoral arterial conductance and blood flows were higher in MgSO\n                      <jats:sub>4<\/jats:sub>\n                      \u2010treated fetuses than controls. After occlusion, fetal heart rate was lower and carotid and femoral arterial conductance and blood flows were higher in MgSO\n                      <jats:sub>4<\/jats:sub>\n                      \u2010treated fetuses than controls. Femoral arterial waveform height and width were increased during MgSO\n                      <jats:sub>4<\/jats:sub>\n                      infusion, consistent with increased stroke volume. MgSO\n                      <jats:sub>4<\/jats:sub>\n                      did not alter the fetal neurophysiological or nuchal electromyographic responses to asphyxia. These data demonstrate that a clinically comparable dose of MgSO\n                      <jats:sub>4<\/jats:sub>\n                      increased FBF and stroke volume without impairing mean arterial pressure (MAP) or carotid blood flow (CaBF) during and immediately after profound asphyxia. Thus, MgSO\n                      <jats:sub>4<\/jats:sub>\n                      may increase perfusion of peripheral vascular beds during adverse perinatal events.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp270614","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T02:05:20Z","timestamp":1434420320000},"page":"1281-1293","source":"Crossref","is-referenced-by-count":25,"title":["Magnesium sulphate and cardiovascular and cerebrovascular adaptations to asphyxia in preterm fetal sheep"],"prefix":"10.1113","volume":"594","author":[{"given":"Robert","family":"Galinsky","sequence":"first","affiliation":[{"name":"The Department of Physiology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne O.","family":"Davidson","sequence":"additional","affiliation":[{"name":"The Department of Physiology University of Auckland  Auckland New 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