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Recently, we have developed enhanced media which both synchronize the neurogenesis of pluripotent stem cell\u2010derived neural progenitors and accelerate their functional maturation; together these media are termed SynaptoJuice. This pair of media are pro\u2010synaptogenic and generate authentic, mature synaptic networks of connected forebrain neurons from a variety of induced pluripotent and embryonic stem cell lines. Such enhanced rate and extent of synchronized maturation of pluripotent stem cell\u2010derived neural progenitor cells generates neurons which are characterized by a relatively hyperpolarized resting membrane potential, higher spontaneous and induced action potential activity, enhanced synaptic activity, more complete development of a mature inhibitory GABA<jats:sub>A<\/jats:sub> receptor phenotype and faster production of electrical network activity when compared to standard differentiation media. This entire process \u2013 from pre\u2010patterned neural progenitor to active neuron \u2013 takes 3\u00a0weeks or less, making it an ideal platform for drug discovery and disease modelling in the fields of human neurodegenerative and neuropsychiatric disorders, such as Huntington's disease, Parkinson's disease, Alzheimer's disease and Schizophrenia.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp7499-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1113\/jp270655","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T10:23:05Z","timestamp":1473675785000},"page":"6583-6594","source":"Crossref","is-referenced-by-count":57,"title":["Improving and accelerating the differentiation and functional maturation of human 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