{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:24:01Z","timestamp":1788474241463,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2015,11,15]],"date-time":"2015-11-15T00:00:00Z","timestamp":1447545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Previous studies indicate a transient reduction in arterial function following large muscle group exercise, but the mechanisms involved are unknown.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Sympathetic nervous system activation may contribute to such reductions through direct effects in the artery wall, or because of decreases in arterial shear stress.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Administration of prazosin (an \u03b1\n                            <jats:sub>1<\/jats:sub>\n                            \u2010adrenoreceptor blocker) abolished the transient reduction in vascular function observed under placebo conditions following exercise. This effect could not be explained by drug\u2010induced changes in arterial shear stress.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These results suggest that sympathetic vasoconstriction directly competes with endothelium\u2010dependent dilator activity to influence post\u2010exercise vascular function.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These findings have implications for understanding the stimuli responsible for exercise\u2010induced adaptations in arterial function and health in humans.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Transient reduction in vascular function following systemic large muscle group exercise has previously been reported in humans. The mechanisms responsible are currently unknown. We hypothesised that sympathetic nervous system activation, induced by cycle ergometer exercise, would contribute to post\u2010exercise reductions in flow\u2010mediated dilatation (FMD). Ten healthy male subjects (28\u00a0\u00b1\u00a05\u00a0years) undertook two 30\u00a0min sessions of cycle exercise at 75% HR\n                      <jats:sub>max<\/jats:sub>\n                      . Prior to exercise, individuals ingested either a placebo or an \u03b1\n                      <jats:sub>1<\/jats:sub>\n                      \u2010adrenoreceptor blocker (prazosin; 0.05\u00a0mg\u00a0kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). Central haemodynamics, brachial artery shear rate (SR) and blood flow profiles were assessed throughout each exercise bout and in response to brachial artery FMD, measured prior to, immediately after and 60\u00a0min after exercise. Cycle exercise increased both mean and antegrade SR (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) with retrograde SR also elevated under both conditions (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Pre\u2010exercise FMD was similar on both occasions, and was significantly reduced (27%) immediately following exercise in the placebo condition (\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03). In contrast, FMD increased (37%) immediately following exercise in the prazosin condition (\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004, interaction effect\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01). Post\u2010exercise FMD remained different between conditions after correction for baseline diameters preceding cuff deflation and also post\u2010deflation SR. No differences in FMD or other variables were evident 60\u00a0min following recovery. Our results indicate that sympathetic vasoconstriction competes with endothelium\u2010dependent dilator activity to determine post\u2010exercise arterial function. These findings have implications for understanding the chronic impacts of interventions, such as exercise training, which affect both sympathetic activity and arterial shear stress.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp270946","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T05:32:54Z","timestamp":1444109574000},"page":"5145-5156","source":"Crossref","is-referenced-by-count":60,"title":["Impact of sympathetic nervous system activity on post\u2010exercise flow\u2010mediated dilatation in humans"],"prefix":"10.1113","volume":"593","author":[{"given":"Ceri L.","family":"Atkinson","sequence":"first","affiliation":[{"name":"School of Sports Science, Exercise and Health The University of Western Australia  Crawley Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nia C.S.","family":"Lewis","sequence":"additional","affiliation":[{"name":"School of Health and Exercise Sciences 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