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Here, we report recent evidence that H<jats:sub>2<\/jats:sub>S is a modulator of low voltage\u2010activated T\u2010type Ca<jats:sup>2+<\/jats:sup>channels, and discriminates between the different subtypes of T\u2010type Ca<jats:sup>2+<\/jats:sup>channel in that it selectively modulates Cav3.2, whilst Cav3.1 and Cav3.3 are unaffected. At high concentrations, H<jats:sub>2<\/jats:sub>S augments Cav3.2 currents, an observation which has led to the suggestion that H<jats:sub>2<\/jats:sub>S exerts its pro\u2010nociceptive effects via this channel, since Cav3.2 plays a central role in sensory nerve excitability. However, at more physiological concentrations, H<jats:sub>2<\/jats:sub>S is seen to inhibit Cav3.2. This inhibitory action requires the presence of the redox\u2010sensitive, extracellular region of the channel which is responsible for tonic metal ion binding and which particularly distinguishes this channel isoform from Cav3.1 and 3.3. Further studies indicate that H<jats:sub>2<\/jats:sub>S may act in a novel manner to alter channel activity by potentiating the zinc sensitivity\/affinity of this binding site. This review discusses the different reports of H<jats:sub>2<\/jats:sub>S modulation of T\u2010type Ca<jats:sup>2+<\/jats:sup>channels, and how such varying effects may impact on nociception given the role of this channel in sensory activity. This subject remains controversial, and future studies are required before the impact of T\u2010type Ca<jats:sup>2+<\/jats:sup>channel modulation by H<jats:sub>2<\/jats:sub>S might be exploited as a novel approach to pain management.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp7089-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1113\/jp270963","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T07:33:15Z","timestamp":1453707195000},"page":"4119-4129","source":"Crossref","is-referenced-by-count":17,"title":["Regulation of the T\u2010type Ca<sup>2+<\/sup>channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H<sub>2<\/sub>S in nociception"],"prefix":"10.1113","volume":"594","author":[{"given":"Jacobo","family":"Elies","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason L.","family":"Scragg","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Boyle","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikita","family":"Gamper","sequence":"additional","affiliation":[{"name":"Faculty of Biological Sciences, School of Biomedical Sciences University of Leeds Leeds UK"},{"name":"Department of Pharmacology Hebei Medical University Shijiazhuang 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