{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:24:41Z","timestamp":1791228281936,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T00:00:00Z","timestamp":1445817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Hypoxia is a major cause of fetal growth restriction, particularly at high altitude, although little is known about its effects on placental phenotype and resource allocation to fetal growth.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In the present study, maternal hypoxia induced morphological and functional changes in the mouse placenta, which depended on the timing and severity of hypoxia, as well as the degree of maternal hypophagia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Hypoxia at 13% inspired oxygen induced beneficial changes in placental morphology, nutrient transport and metabolic signalling pathways associated with little or no change in fetal growth, irrespective of gestational age.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Hypoxia at 10% inspired oxygen adversely affected placental phenotype and resulted in severe fetal growth restriction, which was due partly to maternal hypophagia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>There is a threshold between 13% and 10% inspired oxygen, corresponding to altitudes of \u223c3700\u00a0m and 5800\u00a0m, respectively, at which the mouse placenta no longer adapts to support fetal resource allocation. This has implications for high altitude human pregnancies.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>The placenta adapts its transport capacity to nutritional cues developmentally, although relatively little is known about placental transport phenotype in response to hypoxia, a major cause of fetal growth restriction. The present study determined the effects of both moderate hypoxia (13% inspired O<jats:sub>2<\/jats:sub>) between days (D)11 and D16 or D14 and D19 of pregnancy and severe hypoxia (10% inspired O<jats:sub>2<\/jats:sub>) from D14 to D19 on placental morphology, transport capacity and fetal growth on D16 and D19 (term\u223cD20.5), relative to normoxic mice in 21%\u00a0O<jats:sub>2<\/jats:sub>. Placental morphology adapted beneficially to 13%\u00a0O<jats:sub>2<\/jats:sub>; fetal capillary volume increased at both ages, exchange area increased at D16 and exchange barrier thickness reduced at D19. Exposure to 13%\u00a0O<jats:sub>2<\/jats:sub> had no effect on placental nutrient transport on D16 but increased placental uptake and clearance of <jats:sup>3<\/jats:sup>H\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010glucose at D19. By contrast, 10%\u00a0O<jats:sub>2<\/jats:sub> impaired fetal vascularity, increased barrier thickness and reduced placental <jats:sup>14<\/jats:sup>C\u2010methylaminoisobutyric acid clearance at D19. Consequently, fetal growth was only marginally affected in 13%\u00a0O<jats:sub>2<\/jats:sub> (unchanged at D16 and \u22125% at D19) but was severely restricted in 10%\u00a0O<jats:sub>2<\/jats:sub> (\u221221% at D19). The hypoxia\u2010induced changes in placental phenotype were accompanied by altered placental insulin\u2010like growth factor (IGF)\u20102 expression and insulin\/IGF signalling, as well as by maternal hypophagia depending on the timing and severity of the hypoxia. Overall, the present study shows that the mouse placenta can integrate signals of oxygen and nutrient availability, possibly through the insulin\u2010IGF pathway, to adapt its phenotype and optimize maternal resource allocation to fetal growth during late pregnancy. It also suggests that there is a threshold between 13% and 10% inspired O<jats:sub>2<\/jats:sub> at which these adaptations no longer occur.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp271057","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T10:58:45Z","timestamp":1442487525000},"page":"1341-1356","source":"Crossref","is-referenced-by-count":94,"title":["Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy"],"prefix":"10.1113","volume":"594","author":[{"given":"J. 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