{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:07:13Z","timestamp":1791252433030,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T00:00:00Z","timestamp":1446076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Childhood obesity is associated with precocious oxidative stress, which can contribute to future diseases.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Early overfed rats have increased oxidative stress in liver and plasma at weaning.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The model of litter size reduction causes adipocyte hypertrophy and lower PPAR\u03b3 at weaning, suggesting a decrease in adipocyte proliferation.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Neonatal overfeeding induced by litter size reduction leads to further obesity and other metabolic disorders, such as liver oxidative stress and microsteatosis at adulthood. We hypothesized that overfeeding causes an early redox imbalance at weaning, which could programme the animals to future liver dysfunction. Thus, we studied lipogenesis, adipogenesis, catecholamine status and oxidative balance in weaned overfed pups. To induce early overfeeding, litters were adjusted to three pups at the 3rd day of lactation (SL group). The control group contained 10 pups per litter until weaning (NL group). Peripheral autonomic nerve function was determined <jats:italic>in vivo<\/jats:italic> at 21\u00a0days old. Thereafter, pups were killed for further analysis. Differences were considered significant when <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05. The SL pups presented with a higher visceral adipocyte area, higher content of lipogenic enzymes (ACC, FAS) and with a lower content of adipogenic factors (CEBP, PPAR\u03b3) in visceral adipose tissue (VAT). Although autonomic nerve activity and adrenal catecholamine production were not significantly altered, catecholamine receptor (\u03b23ADR) content was lower in VAT. The SL pups also presented with higher triglyceride, PPAR\u03b3, PPAR\u03b1 and PGC1\u03b1 contents in liver. In plasma and liver, the SL pups showed an oxidative imbalance, with higher lipid peroxidation and protein oxidation. The SL group presented with a higher serum alanine aminotransferase (ALT). The early increase in lipogenesis in adipose tissue and liver in weaned overfed rats suggests that the higher oxidative stress and lower catecholamine content in VAT are associated with the early development of liver dysfunction and adipocyte hypertrophy.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp271189","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T20:32:24Z","timestamp":1441225944000},"page":"4799-4811","source":"Crossref","is-referenced-by-count":12,"title":["Early redox imbalance is associated with liver dysfunction at weaning in overfed rats"],"prefix":"10.1113","volume":"593","author":[{"given":"E. P. S.","family":"Concei\u00e7\u00e3o","sequence":"first","affiliation":[{"name":"Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute State University of Rio de Janeiro  RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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