{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:41:24Z","timestamp":1792460484098,"version":"4.5.0"},"reference-count":102,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T00:00:00Z","timestamp":1462579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2016,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Skeletal muscles undergo structural and functional decline with ageing, culminating in sarcopenia. The underlying neuromuscular mechanisms have been the subject of intense investigation, revealing mitochondrial abnormalities as potential culprits within both nerve and muscle cells. Implicated mechanisms involve impaired mitochondrial dynamics, reduced organelle biogenesis and quality control via mitophagy, accumulation of mitochondrial DNA (mtDNA) damage and respiratory chain defect, metabolic disturbance, pro\u2010apoptotic signalling, and oxidative stress. This article provides an overview of the cellular mechanisms whereby mitochondria may promote maladaptive changes within motor neurons, the neuromuscular junction (NMJ) and muscle fibres. Lifelong physical activity, which promotes mitochondrial health across tissues, is emerging as an effective countermeasure for sarcopenia.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp7177-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp271212","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T09:44:17Z","timestamp":1456566257000},"page":"4499-4512","source":"Crossref","is-referenced-by-count":162,"title":["The ageing neuromuscular system and sarcopenia: a mitochondrial perspective"],"prefix":"10.1113","volume":"594","author":[{"given":"Karolina A.","family":"Rygiel","sequence":"first","affiliation":[{"name":"Newcastle University Centre for Ageing and Vitality  Newcastle upon Tyne UK"},{"name":"Wellcome Trust Centre for Mitochondrial Research  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Picard","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine, Department of Psychiatry, College of Physicians and Surgeons, Columbia University Columbia University Medical Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug M.","family":"Turnbull","sequence":"additional","affiliation":[{"name":"Newcastle University Centre for Ageing and Vitality  Newcastle upon Tyne UK"},{"name":"Wellcome Trust Centre for Mitochondrial Research  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,7]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2012.01308.x"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2014.12.001"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.07.013"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37048"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.12.003"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1215233"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/917085"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.01.001"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05913"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.12.2652"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.010389"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00420.2011"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb836"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03638-4"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/89.4.251"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00139.2004"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880110503"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/507132"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01102.2001"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.142109"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2014.0500183"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2012.03.002"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.4081\/bam.2014.1.5"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-110410-132529"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2006.06.004"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.026"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp179"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002102200"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2275"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi307"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-276337"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2578fje"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.03.019"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-2395-2-13"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-242750"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2247"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.029"},{"key":"e_1_2_2_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00211"},{"key":"e_1_2_2_41_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.61.070192.003553"},{"key":"e_1_2_2_42_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-146308"},{"key":"e_1_2_2_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.08.029"},{"key":"e_1_2_2_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu221"},{"key":"e_1_2_2_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069327"},{"key":"e_1_2_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.03.034"},{"key":"e_1_2_2_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt107"},{"key":"e_1_2_2_48_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.5.5.809"},{"key":"e_1_2_2_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.f.94"},{"key":"e_1_2_2_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.02.007"},{"key":"e_1_2_2_51_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0349"},{"key":"e_1_2_2_52_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4235"},{"key":"e_1_2_2_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.5.1011S"},{"key":"e_1_2_2_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293457"},{"key":"e_1_2_2_55_1","first-page":"239","article-title":"Variability in muscle fibre areas in whole human quadriceps muscle: effects of increasing age","volume":"174","author":"Lexell J","year":"1991","journal-title":"J Anat"},{"key":"e_1_2_2_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1419651112"},{"key":"e_1_2_2_57_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21889"},{"key":"e_1_2_2_58_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.181743"},{"key":"e_1_2_2_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.10.008"},{"key":"e_1_2_2_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2008.02066.x"},{"key":"e_1_2_2_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/embj.201385902"},{"key":"e_1_2_2_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2006.03.010"},{"key":"e_1_2_2_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2012.04.003"},{"key":"e_1_2_2_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/90116"},{"key":"e_1_2_2_65_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/814096"},{"key":"e_1_2_2_66_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201206-0982OC"},{"key":"e_1_2_2_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2011.00745.x"},{"key":"e_1_2_2_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00584.2012"},{"key":"e_1_2_2_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414028111"},{"key":"e_1_2_2_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007934"},{"key":"e_1_2_2_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12091"},{"key":"e_1_2_2_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107402108"},{"key":"e_1_2_2_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029082"},{"key":"e_1_2_2_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041817"},{"key":"e_1_2_2_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.02.027"},{"key":"e_1_2_2_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12149"},{"key":"e_1_2_2_77_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.211466"},{"key":"e_1_2_2_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690450"},{"key":"e_1_2_2_79_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501559102"},{"key":"e_1_2_2_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.128"},{"key":"e_1_2_2_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.05.024"},{"key":"e_1_2_2_82_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.45.10.870"},{"key":"e_1_2_2_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr500295n"},{"key":"e_1_2_2_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3966"},{"key":"e_1_2_2_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1332551100"},{"key":"e_1_2_2_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.06.040"},{"key":"e_1_2_2_87_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00472.2006"},{"key":"e_1_2_2_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1606"},{"key":"e_1_2_2_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(97)00087-2"},{"key":"e_1_2_2_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.259.1.E96"},{"key":"e_1_2_2_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(77)90069-7"},{"key":"e_1_2_2_92_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01107.2012"},{"key":"e_1_2_2_93_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00292.2010"},{"key":"e_1_2_2_94_1","first-page":"84","article-title":"The relationship between skeletal muscle mitochondrial citrate synthase activity and whole body oxygen uptake adaptations in response to exercise training","volume":"6","author":"Vigelso A","year":"2014","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"e_1_2_2_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2011.03.006"},{"key":"e_1_2_2_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2010.00139"},{"key":"e_1_2_2_97_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61398"},{"key":"e_1_2_2_98_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911570106"},{"key":"e_1_2_2_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3013"},{"key":"e_1_2_2_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2009.11.002"},{"key":"e_1_2_2_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80611-X"},{"key":"e_1_2_2_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1219855"},{"key":"e_1_2_2_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.11.008"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FJP271212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP271212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T19:05:18Z","timestamp":1696014318000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP271212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,7]]},"references-count":102,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2016,8,15]]}},"alternative-id":["10.1113\/JP271212"],"URL":"https:\/\/doi.org\/10.1113\/jp271212","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,7]]}}}