{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:20:55Z","timestamp":1788916855687,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2016,3,15]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Intrauterine growth restriction (IUGR) is associated with short\u2010 and long\u2010term detrimental cardiometabolic effects.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Mice and rats are commonly used to assess IUGR, but differences in placental and fetal developmental physiology relative to those in humans highlight the need for alternative small animal IUGR models.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We developed a guinea pig IUGR model by gradual occlusion of uterine arteries by ameroid constrictor implantation. In this model, reduced uterine blood flow was associated with IUGR, allowing <jats:italic>in vivo<\/jats:italic> assessment of fetal growth trajectory and umbilico\u2010placental vascular function in conscious animals.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The intervention induces placental vascular dysfunction and remodelling, as well as altered fetal abdominal growth resulting in an asymmetric IUGR and preserved brain growth.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Intra\u2010uterine growth restriction (IUGR) is associated with short and long\u2010term metabolic and cardiovascular alterations. Mice and rats have been extensively used to study the effects of IUGR, but there are notable differences in fetal and placental physiology relative to those of humans that argue for alternative animal models. This study proposes that gradual occlusion of uterine arteries from mid\u2010gestation in pregnant guinea pigs produces a novel model to better assess human IUGR. Fetal biometry and <jats:italic>in vivo<\/jats:italic> placental vascular function were followed by sonography and Doppler of control pregnant guinea pigs and sows submitted to surgical placement of ameroid constrictors in both uterine arteries (IUGR) at mid\u2010gestation (35\u00a0days). The ameroid constrictors induced a reduction in the fetal abdominal circumference growth rate (0.205\u00a0cm\u00a0day<jats:sup>\u22121<\/jats:sup>) compared to control (0.241\u00a0cm\u00a0day<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) without affecting biparietal diameter growth. Umbilical artery pulsatility and resistance indexes at 10 and 20\u00a0days after surgery were significantly higher in IUGR animals than controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). These effects were associated with a decrease in the relative luminal area of placental chorionic arteries (21.3\u00a0\u00b1\u00a02.2% <jats:italic>vs<\/jats:italic>. 33.2\u00a0\u00b1\u00a02.7%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) in IUGR sows at near term. Uterine artery intervention reduced fetal (\u223c30%), placental (\u223c20%) and liver (\u223c50%) weights (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), with an increased brain to liver ratio (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) relative to the control group. These data demonstrate that the ameroid constrictor implantations in uterine arteries in pregnant guinea pigs lead to placental vascular dysfunction and altered fetal growth that induces asymmetric IUGR.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp271467","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T07:24:52Z","timestamp":1451546692000},"page":"1553-1561","source":"Crossref","is-referenced-by-count":34,"title":["Assessment of <i>in vivo<\/i> fetal growth and placental vascular function in a novel intrauterine growth restriction model of progressive uterine artery occlusion in guinea pigs"],"prefix":"10.1113","volume":"594","author":[{"given":"Emilio A.","family":"Herrera","sequence":"first","affiliation":[{"name":"Programa de Fisiopatolog\u00eda, Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina Universidad de Chile  Av. 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