{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:38:50Z","timestamp":1761964730435},"reference-count":85,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Key points<\/jats:title>\nThe mechanism(s) that regulate hypoxia\u2010induced blood flow through intrapulmonary arteriovenous anastomoses (Q<\/jats:italic>IPAVA<\/jats:sub>) are currently unknown.<\/jats:p><\/jats:list-item>\nOur previous work has demonstrated that the mechanism of hypoxia\u2010induced Q<\/jats:italic>IPAVA<\/jats:sub> is not simply increased cardiac output, pulmonary artery systolic pressure or sympathetic nervous system activity and, instead, it may be a result of hypoxaemia directly.<\/jats:p><\/jats:list-item>\nTo determine whether it is reduced arterial () or O2<\/jats:sub> content () that causes hypoxia\u2010induced Q<\/jats:italic>IPAVA<\/jats:sub>, individuals were instructed to breathe room air and three levels of hypoxic gas at rest before (control) and after was reduced by 10% by lowering the haemoglobin concentration (isovolaemic haemodilution; Low [Hb]).<\/jats:p><\/jats:list-item>\nQ<\/jats:italic>IPAVA<\/jats:sub>, assessed by transthoracic saline contrast echocardiography, significantly increased as decreased and, despite reduced (via isovolaemic haemodilution), was similar at iso\u2010.<\/jats:p><\/jats:list-item>\nThese data suggest that, with alveolar hypoxia, low causes the hypoxia\u2010induced increase in Q<\/jats:italic>IPAVA<\/jats:sub>, although where and how this is detected remains unknown.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>Abstract<\/jats:title>Alveolar hypoxia causes increased blood flow through intrapulmonary arteriovenous anastomoses (Q<\/jats:italic>IPAVA<\/jats:sub>) in healthy humans at rest. However, it is unknown whether the stimulus regulating hypoxia\u2010induced Q<\/jats:italic>IPAVA<\/jats:sub> is decreased arterial () or O2<\/jats:sub> content (). is known to regulate blood flow in the systemic circulation and it is suggested that IPAVA may be regulated similar to the systemic vasculature. Thus, we hypothesized that reduced would be the stimulus for hypoxia\u2010induced Q<\/jats:italic>IPAVA<\/jats:sub>. Blood volume (BV) was measured using the optimized carbon monoxide rebreathing method in 10 individuals. Less than 5\u00a0days later, subjects breathed room air, as well as 18%, 14% and 12.5% O2<\/jats:sub>, for 30\u00a0min each, in a randomized order, before (CON) and after isovolaemic haemodilution (10% of BV withdrawn and replaced with an equal volume of 5% human serum albumin\u2013saline mixture) to reduce [Hb] (Low [Hb]). was measured at the end of each condition and Q<\/jats:italic>IPAVA<\/jats:sub> was assessed using transthoracic saline contrast echocardiography. [Hb] was reduced from 14.2\u00a0\u00b1\u00a00.8 to 12.8\u00a0\u00b1\u00a00.7\u00a0g\u00a0dl\u22121<\/jats:sup> (10\u00a0\u00b1\u00a02% reduction) from CON to Low [Hb] conditions. was no different between CON and Low [Hb], although was 10.4%, 9.2% and 9.8% lower at 18%, 14% and 12.5% O2<\/jats:sub>, respectively. Q<\/jats:italic>IPAVA<\/jats:sub> significantly increased as decreased and, despite reduced , was similar at iso\u2010. These data suggest that, with alveolar hypoxia, low causes the hypoxia\u2010induced increase in Q<\/jats:italic>IPAVA<\/jats:sub>. Whether the low is detected at the carotid body, airway and\/or the vasculature remains unknown.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp272211","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T17:42:03Z","timestamp":1460310123000},"page":"4981-4996","source":"Crossref","is-referenced-by-count":26,"title":["Decreased arterial , not O2<\/sub> content, increases blood flow through intrapulmonary arteriovenous anastomoses at rest"],"prefix":"10.1113","volume":"594","author":[{"given":"Joseph W.","family":"Duke","sequence":"first","affiliation":[{"name":"Ohio University Division of Exercise Physiology Athens OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T.","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Oregon Department of Human Physiology Eugene OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin 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