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Blockade of these receptors is thought to interfere with the activity of coordinating interneurons, a conclusion derived primarily from<jats:italic>in vitro<\/jats:italic>studies on isolated spinal cord of neonatal rats and mice. Developmental changes in the effects of serotonin (5\u2010HT) on spinal neurons have recently been described, and there is increasing data on control of sensory input by 5\u2010HT<jats:sub>7<\/jats:sub>receptors on dorsal root ganglion cells and\/or dorsal horn neurons, leading us to determine the effects of 5\u2010HT<jats:sub>7<\/jats:sub>receptor blockade on voluntary overground locomotion and on locomotion without afferent input from the moving limb (fictive locomotion) in adult animals. Intrathecal injections of the selective 5\u2010HT<jats:sub>7<\/jats:sub>antagonist SB269970 in adult intact rats suppressed locomotion by partial paralysis of hindlimbs. This occurred without a direct effect on motoneurons as revealed by an investigation of reflex activity. The antagonist disrupted intra\u2010 and interlimb coordination during locomotion in all intact animals but not during fictive locomotion induced by stimulation of the mesencephalic locomotor region (MLR). MLR\u2010evoked fictive locomotion was transiently blocked, then the amplitude and frequency of rhythmic activity were reduced by SB269970, consistent with the notion that the MLR activates 5\u2010HT neurons, leading to excitation of central pattern generator neurons with 5\u2010HT<jats:sub>7<\/jats:sub>receptors. Effects on coordination in adults required the presence of afferent input, suggesting a switch to 5\u2010HT<jats:sub>7<\/jats:sub>receptor\u2010mediated control of sensory pathways during development.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp272271","type":"journal-article","created":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T08:57:07Z","timestamp":1468054627000},"page":"301-320","source":"Crossref","is-referenced-by-count":57,"title":["Serotonin controls initiation of locomotion and afferent modulation of coordination via 5\u2010HT<sub>7<\/sub>receptors in adult rats"],"prefix":"10.1113","volume":"595","author":[{"given":"Anna M.","family":"Cabaj","sequence":"first","affiliation":[{"name":"Department of Neurophysiology Nencki Institute of Experimental Biology PAS 02\u2010093 Warsaw Poland"},{"name":"Department of Nerve\u2010Muscle Engineering Institute of Biocybernetics and Biomedical Engineering PAS 02\u2010109 Warsaw 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