{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:34:34Z","timestamp":1791614074984,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH Heart, Lung, and Blood Institute","award":["HL-103786"],"award-info":[{"award-number":["HL-103786"]}]},{"name":"NIH Heart, Lung, and Blood Institute","award":["HL-116579"],"award-info":[{"award-number":["HL-116579"]}]},{"name":"NIH Heart, Lung, and Blood Institute","award":["HL-091830"],"award-info":[{"award-number":["HL-091830"]}]},{"name":"Veterans Affairs Rehabilitation Research and Development Merit","award":["E6910-R"],"award-info":[{"award-number":["E6910-R"]}]},{"name":"Veterans Affairs Rehabilitation Research and Development Merit","award":["E1697-R"],"award-info":[{"award-number":["E1697-R"]}]},{"name":"Spire","award":["E1572-P, E1433-P"],"award-info":[{"award-number":["E1572-P, E1433-P"]}]},{"name":"Senior Research Career Scientist","award":["E9275-L"],"award-info":[{"award-number":["E9275-L"]}]},{"name":"French Ministry of Higher Education","award":["CIFRE 2012\/0445"],"award-info":[{"award-number":["CIFRE 2012\/0445"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2016,9,15]]},"abstract":"<jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The purpose of this study was to determine the role of group III\/IV muscle afferents in limiting the endurance exercise\u2010induced metabolic perturbation assayed in muscle biopsy samples taken from locomotor muscle.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Lumbar intrathecal fentanyl was used to attenuate the central projection of \u03bc\u2010opioid receptor\u2010sensitive locomotor muscle afferents during a 5\u00a0km cycling time trial.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The findings suggest that the central projection of group III\/IV muscle afferent feedback constrains voluntary neural \u2018drive\u2019 to working locomotor muscle and limits the exercise\u2010induced intramuscular metabolic perturbation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Therefore, the CNS might regulate the degree of metabolic perturbation within locomotor muscle and thereby limit peripheral fatigue. It appears that the group III\/IV muscle afferents are an important neural link in this regulatory mechanism, which probably serves to protect locomotor muscle from the potentially severe functional impairment as a consequence of severe intramuscular metabolic disturbance.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      To investigate the role of metabo\u2010 and mechanosensitive group III\/IV muscle afferents in limiting the intramuscular metabolic perturbation during whole body endurance exercise, eight subjects performed 5\u00a0km cycling time trials under control conditions (CTRL) and with lumbar intrathecal fentanyl impairing lower limb muscle afferent feedback (FENT). Vastus lateralis muscle biopsies were obtained before and immediately after exercise. Motoneuronal output was estimated through vastus lateralis surface electromyography (EMG). Exercise\u2010induced changes in intramuscular metabolites were determined using liquid and gas chromatography\u2010mass spectrometry. Quadriceps fatigue was quantified by pre\u2010 to post\u2010exercise changes in potentiated quadriceps twitch torque (\u0394QT\n                      <jats:sub>single<\/jats:sub>\n                      ) evoked by electrical femoral nerve stimulation. Although motoneuronal output was 21\u00a0\u00b1\u00a012% higher during FENT compared to CTRL (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\u00a00.05), time to complete the time trial was similar (\u223c8.8\u00a0min). Compared to CTRL, power output during FENT was 10\u00a0\u00b1\u00a04% higher in the first half of the time trial, but 11\u00a0\u00b1\u00a05% lower in the second half (both\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). The exercise\u2010induced increase in intramuscular inorganic phosphate, H\n                      <jats:sup>+<\/jats:sup>\n                      , adenosine diphosphate, lactate and phosphocreatine depletion was 55\u00a0\u00b1\u00a030, 62\u00a0\u00b1\u00a018, 129\u00a0\u00b1\u00a063, 47\u00a0\u00b1\u00a014 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and 27\u00a0\u00b1\u00a014% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) greater in FENT than CTRL. \u0394QT\n                      <jats:sub>single<\/jats:sub>\n                      was greater following FENT than CTRL (\u221252\u00a0\u00b1\u00a02\u00a0\n                      <jats:italic>vs<\/jats:italic>\n                      \u221231\u00a0\u00b1\u00a01%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and this difference was positively correlated with the difference in inorganic phosphate (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.79;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) and H\n                      <jats:sup>+<\/jats:sup>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.92;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). In conclusion, during whole body exercise, group III\/IV muscle afferents provide feedback to the CNS which, in turn, constrains motoneuronal output to the active skeletal muscle. This regulatory mechanism limits the exercise\u2010induced intramuscular metabolic perturbation, preventing an abnormal homeostatic challenge and excessive peripheral fatigue.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp272283","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T05:26:44Z","timestamp":1464672404000},"page":"5303-5315","source":"Crossref","is-referenced-by-count":173,"title":["Group III\/IV muscle afferents limit the intramuscular metabolic perturbation during whole body exercise in humans"],"prefix":"10.1113","volume":"594","author":[{"given":"Gregory M.","family":"Blain","sequence":"first","affiliation":[{"name":"LAMHESS, EA 6312 University Nice Sophia Antipolis University of Toulon  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler S.","family":"Mangum","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simranjit K.","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Utah  Salt Lake City UT USA"},{"name":"Discipline of Physiology, School of Medicine The University of Adelaide  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Weavil","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Hureau","sequence":"additional","affiliation":[{"name":"LAMHESS, EA 6312 University Nice Sophia Antipolis University of Toulon  Nice France"},{"name":"Department of Medicine University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob 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