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Myocytes are responsible for electrical conduction and contractile force generation, while the other cell types are responsible for matrix deposition, vascularization, and injury response. Myocytes and non\u2010myocytes are\u00a0known to communicate and exert mutual regulatory effects. In concert, they determine the structural, electrical and mechanical characteristics in the healthy and remodelled myocardium. Dynamic crosstalk between myocytes and non\u2010myocytes plays a crucial role in stress\/injury\u2010induced hypertrophy and fibrosis development that can ultimately lead to heart failure and arrhythmias. Investigations of heterocellular communication in the myocardium are hampered by the intricate interspersion of the different cell types and the complexity of the tissue architecture. <jats:italic>In\u00a0vitro<\/jats:italic> models have facilitated investigations of cardiac cells in a direct and controllable manner and have provided important functional and mechanistic insights. However, these cultures often lack regulatory input from the other cell types as well as additional topographical, electrical, mechanical and biochemical cues from the cardiac microenvironment that all contribute to modulating cell differentiation, maturation, alignment, function and survival. Advancements in the development of more complex pluricellular physiological platforms that incorporate diverse cues from the myocardial microenvironment are expected to lead to more physiologically relevant cardiac tissue\u2010like <jats:italic>in\u00a0vitro<\/jats:italic> models for mechanistic biological research, disease modelling, therapeutic target identification, drug testing and regeneration.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp12233-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1113\/jp273100","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T02:52:51Z","timestamp":1485226371000},"page":"3891-3905","source":"Crossref","is-referenced-by-count":50,"title":["<i>In vitro<\/i> models of the cardiac microenvironment to study myocyte and non\u2010myocyte crosstalk: bioinspired approaches beyond the polystyrene dish"],"prefix":"10.1113","volume":"595","author":[{"given":"Celinda M.","family":"Kofron","sequence":"first","affiliation":[{"name":"Cardiovascular Research Center, Cardiovascular Institute Rhode Island Hospital and Alpert Medical School of Brown University  Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3362-6072","authenticated-orcid":false,"given":"Ulrike","family":"Mende","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Cardiovascular Institute Rhode Island Hospital and Alpert Medical School of Brown University  Providence RI 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