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The routes of communication between the microbiota and brain are being unravelled and include the vagus nerve, gut hormone signalling, the immune system, tryptophan metabolism or by way of microbial metabolites such as short chain fatty acids. The importance of early life gut microbiota in shaping future health outcomes is also emerging. Disturbances of this composition by way of antibiotic exposure, lack of breastfeeding, infection, stress and the environmental influences coupled with the influence of host genetics can result in long\u2010term effects on physiology and behaviour, at least in animal models. It is also worth noting that mode of delivery at birth influences microbiota composition with those born by Caesarean section having a distinctly different microbiota in early life to those born <jats:italic>per vaginum<\/jats:italic>. At the other extreme of life, ageing is associated with a narrowing in microbial diversity and healthy ageing correlates with a diverse microbiome. Recently, the gut microbiota has been implicated in a variety of conditions including depression, autism, schizophrenia and Parkinson's disease. There is still considerable debate as to whether or not the gut microbiota changes are core to the pathophysiology of such conditions or are merely epiphenomenal. It is plausible that such neuropsychiatric disorders might be treated in the future by targeting the microbiota either by microbiota transplantation, antibiotics or psychobiotics.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp12018-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1113\/jp273106","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T06:23:07Z","timestamp":1474266187000},"page":"489-503","source":"Crossref","is-referenced-by-count":713,"title":["Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration"],"prefix":"10.1113","volume":"595","author":[{"given":"Timothy G.","family":"Dinan","sequence":"first","affiliation":[{"name":"APC Microbiome Institute University College Cork  Ireland"},{"name":"Department of Psychiatry and Neurobehavioural Science University College Cork  Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5887-2723","authenticated-orcid":false,"given":"John F.","family":"Cryan","sequence":"additional","affiliation":[{"name":"APC Microbiome Institute University College Cork  Ireland"},{"name":"Department of Anatomy and Neuroscience University College Cork  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