{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:46:56Z","timestamp":1740134816630,"version":"3.37.3"},"reference-count":75,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007586","name":"Aix-Marseille Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Vagal sensory inputs transmit information from the viscera to brainstem neurones located in the nucleus tractus solitarii to set physiological parameters. These excitatory synapses exhibit a CB1 endocannabinoid\u2010induced long\u2010term depression (LTD) triggered by vagal fibre stimulation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We investigated the impact of nutritional status on long\u2010term changes in this long\u2010term synaptic plasticity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Food deprivation prevents LTD induction by disrupting CB1 receptor signalling. Short\u2010term refeeding restores the capacity of vagal synapses to express LTD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Ghrelin and cholecystokinin, respectively released during fasting and refeeding, play a key role in the control of LTD via the activation of energy sensing pathways such as AMPK and the mTOR and ERK pathways.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Communication form the viscera to the brain is essential to set physiological homoeostatic parameters but also to drive more complex behaviours such as mood, memory and emotional states. Here we investigated the impact of the nutritional status on long\u2010term changes in excitatory synaptic transmission in the nucleus tractus solitarii, a neural hub integrating visceral signals. These excitatory synapses exhibit a CB1 endocannabinoid (eCB)\u2010induced long\u2010term depression (LTD) triggered by vagal fibre stimulation. Since eCB signalling is known to be an important component of homoeostatic regulation of the body and is regulated during various stressful conditions, we tested the hypothesis that food deprivation alters eCB signalling in central visceral afferent fibres. Food deprivation prevents eCB\u2010LTD induction due to the absence of eCB signalling. This loss was reversed by blockade of ghrelin receptors. Activation of the cellular fuel sensor AMP\u2010activated protein kinase or inhibition of the mechanistic target of rapamycin pathway abolished eCB\u2010LTD in free\u2010fed rats. Signals associated with energy surfeit, such as short\u2010term refeeding, restore eCB\u2010LTD induction, which in turn requires activation of cholecystokinin receptors and the extracellular signal\u2010regulated kinase pathway. These data suggest a tight link between eCB\u2010LTD in the NTS and nutritional status and shed light on the key role of eCB in the integration of visceral information.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp273484","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T07:52:41Z","timestamp":1487922761000},"page":"3267-3285","source":"Crossref","is-referenced-by-count":3,"title":["Nutritional status\u2010dependent endocannabinoid signalling regulates the integration of rat visceral information"],"prefix":"10.1113","volume":"595","author":[{"given":"Abdessattar","family":"Khlaifia","sequence":"first","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, CNRS CRN2M  UMR 7286, 51 Boulevard Pierre Dramard 13344 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Matias","sequence":"additional","affiliation":[{"name":"INSERM, Neurocentre Magendie Physiopathologie de la Plasticit\u00e9 Neuronale, U1215 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