{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:32Z","timestamp":1787016272163,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Herbert T. Abelson Chair"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2017,4,15]]},"abstract":"<jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Late gestation during pregnancy has been associated with a relatively high prevalence of obstructive sleep apnoea (OSA).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Intermittent hypoxia, a hallmark of OSA, could impose significant long\u2010term effects on somatic growth, energy homeostasis and metabolic function in offspring.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Here we show that late gestation intermittent hypoxia induces metabolic dysfunction as reflected by increased body weight and adiposity index in adult male offspring that is paralleled by epigenomic alterations and inflammation in visceral white adipose tissue.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Fetal perturbations by OSA during pregnancy impose long\u2010term detrimental effects manifesting as metabolic dysfunction in adult male offspring.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Pregnancy, particularly late gestation (LG), has been associated with a relatively high prevalence of obstructive sleep apnoea (OSA). Intermittent hypoxia (IH), a hallmark of OSA, could impose significant long\u2010term effects on somatic growth, energy homeostasis, and metabolic function in offspring. We hypothesized that IH during late pregnancy (LG\u2010IH) may increase the propensity for metabolic dysregulation and obesity in adult offspring via epigenetic modifications. Time\u2010pregnant female C57BL\/6 mice were exposed to LG\u2010IH or room air (LG\u2010RA) during days 13\u201318 of gestation. At 24\u00a0weeks, blood samples were collected from offspring mice for lipid profiles and insulin resistance, indirect calorimetry was performed and visceral white adipose tissues (VWAT) were assessed for inflammatory cells as well as for differentially methylated gene regions (DMRs) using a methylated DNA immunoprecipitation on chip (MeDIP\u2010chip). Body weight, food intake, adiposity index, fasting insulin, triglycerides and cholesterol levels were all significantly higher in LG\u2010IH male but not female offspring. LG\u2010IH also altered metabolic expenditure and locomotor activities in male offspring, and increased number of pro\u2010inflammatory macrophages emerged in VWAT along with 1520\u00a0DMRs (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\u00a00.0001), associated with 693\u00a0genes. Pathway analyses showed that genes affected by LG\u2010IH were mainly associated with molecular processes related to metabolic regulation and inflammation. LG\u2010IH induces metabolic dysfunction as reflected by increased body weight and adiposity index in adult male offspring that is paralleled by epigenomic alterations and inflammation in VWAT. Thus, perturbations to fetal environment by OSA during pregnancy can have long\u2010term detrimental effects on the fetus, and lead to persistent metabolic dysfunction in adulthood.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp273570","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T22:52:45Z","timestamp":1484520765000},"page":"2551-2568","source":"Crossref","is-referenced-by-count":56,"title":["Late gestational intermittent hypoxia induces metabolic and epigenetic changes in male adult offspring mice"],"prefix":"10.1113","volume":"595","author":[{"given":"Abdelnaby","family":"Khalyfa","sequence":"first","affiliation":[{"name":"Section of Pediatric Sleep Medicine, Department of Pediatrics University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Cortese","sequence":"additional","affiliation":[{"name":"Section of Pediatric Sleep Medicine, Department of Pediatrics University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuanhong","family":"Qiao","sequence":"additional","affiliation":[{"name":"Section of Pediatric Sleep Medicine, Department of Pediatrics University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honggang","family":"Ye","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Metabolism, Department of Medicine University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyue","family":"Bao","sequence":"additional","affiliation":[{"name":"Center for Research Informatics, Pritzker School of Medicine, Biological Sciences Division University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Andrade","sequence":"additional","affiliation":[{"name":"Center for Research Informatics, Pritzker School of Medicine, 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