{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:31:31Z","timestamp":1789558291209,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"am","delay-in-days":289,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["J 3595\u2010B19"],"award-info":[{"award-number":["J 3595\u2010B19"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP110101941"],"award-info":[{"award-number":["DP110101941"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Lung aeration at birth significantly increases pulmonary blood flow, which is unrelated to increased oxygenation or other spatial relationships that match ventilation to perfusion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Using simultaneous X\u2010ray imaging and angiography in near\u2010term rabbits, we investigated the relative contributions of the vagus nerve and oxygenation to the increase in pulmonary blood flow at birth.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Vagal denervation inhibited the global increase in pulmonary blood flow induced by partial lung aeration, although high inspired oxygen concentrations can partially mitigate this effect.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results of the present study indicate that a vagal reflex may mediate a rapid global increase in pulmonary blood flow in response to partial lung aeration.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Air entry into the lungs at birth triggers major cardiovascular changes, including a large increase in pulmonary blood flow (PBF) that is not spatially related to regional lung aeration. To investigate the possible underlying role of a vagally\u2010mediated stimulus, we used simultaneous phase\u2010contrast X\u2010ray imaging and angiography in near\u2010term (30\u00a0days of gestation) vagotomized (<jats:italic>n\u00a0=\u00a0<\/jats:italic>15) or sham\u2010operated (<jats:italic>n\u00a0=\u00a0<\/jats:italic>15) rabbit kittens. Rabbits were imaged before ventilation, when one lung was ventilated (unilateral) with 100% nitrogen (N<jats:sub>2<\/jats:sub>), air or 100% oxygen (O<jats:sub>2<\/jats:sub>), and after all kittens were switched to unilateral ventilation in air and then ventilation of both lungs using air. Compared to control kittens, vagotomized kittens had little or no increase in PBF in both lungs following unilateral ventilation when ventilation occurred with 100% N<jats:sub>2<\/jats:sub> or with air. However, relative PBF did increase in vagotomized animals ventilated with 100% O<jats:sub>2<\/jats:sub>, indicating the independent stimulatory effects of local oxygen concentration and autonomic innervation on the changes in PBF at birth. These findings demonstrate that vagal denervation inhibits the previously observed increase in PBF with partial lung aeration, although high inspired oxygen concentrations can partially mitigate this effect.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp273682","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T19:14:25Z","timestamp":1480533265000},"page":"1593-1606","source":"Crossref","is-referenced-by-count":21,"title":["Vagal denervation inhibits the increase in pulmonary blood flow during partial lung aeration at birth"],"prefix":"10.1113","volume":"595","author":[{"given":"Justin A.\u00a0R.","family":"Lang","sequence":"first","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research  Melbourne Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Pearson","sequence":"additional","affiliation":[{"name":"Monash Biomedical Imaging Facility and Department of Physiology Monash University  Melbourne Australia"},{"name":"Australian Synchrotron  Melbourne Australia"},{"name":"Department of Cardiac Physiology National Cerebral and Cardiovascular Centre Research Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Binder\u2010Heschl","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research  Melbourne Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University  Melbourne Australia"},{"name":"Medical University of Graz  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan J.","family":"Wallace","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research  Melbourne Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa L.","family":"Siew","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research  Melbourne Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus J.","family":"Kitchen","sequence":"additional","affiliation":[{"name":"School of Physics and Astronomy Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan B.","family":"te Pas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Leiden University Medical Centre  Leiden Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Medical Imaging and Radiation Sciences Monash University  Melbourne 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