{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:28:51Z","timestamp":1783351731046,"version":"3.54.6"},"reference-count":53,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Australian Government Research Training Program"},{"name":"Gretel and Gordon Bootes Medical Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>The brainstem dorsal column nuclei (DCN) process sensory information arising from the body before it reaches the brain and becomes conscious.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Despite significant investigations into sensory coding in peripheral nerves and the somatosensory cortex, little is known about how sensory information arising from the periphery is represented in the DCN.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Following stimulation of hind\u2010limb nerves, we mapped and characterised the evoked electrical signatures across the DCN surface.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We show that evoked responses recorded from the DCN surface are highly reproducible and are unique to nerves carrying specific sensory information.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>The brainstem dorsal column nuclei (DCN) play a role in early processing of somatosensory information arising from a variety of functionally distinct peripheral structures, before being transmitted to the cortex via the thalamus. To improve our understanding of how sensory information is represented by the DCN, we characterised and mapped low\u2010 (&lt;200\u00a0Hz) and high\u2010frequency (550\u20133300\u00a0Hz) components of nerve\u2010evoked DCN surface potentials. DCN surface potentials were evoked by electrical stimulation of the left and right nerves innervating cutaneous structures (sural nerve), or a mix of cutaneous and deep structures (peroneal nerve), in 8\u2010week\u2010old urethane\u2010anaesthetised male Wistar rats. Peroneal nerve\u2010evoked DCN responses demonstrated low\u2010frequency events with significantly longer durations, more high\u2010frequency events and larger magnitudes compared to responses evoked from sural nerve stimulation. Hotspots of low\u2010 and high\u2010frequency DCN activity were found ipsilateral to stimulated nerves but were not symmetrically organised. In conclusion, we find that sensory inputs from peripheral nerves evoke unique and characteristic DCN activity patterns that are highly reproducible both within and across animals.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp273759","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T09:33:44Z","timestamp":1490348024000},"page":"4507-4524","source":"Crossref","is-referenced-by-count":13,"title":["Characterisation and functional mapping of surface potentials in the rat dorsal column nuclei"],"prefix":"10.1113","volume":"595","author":[{"given":"Alastair J.","family":"Loutit","sequence":"first","affiliation":[{"name":"The Eccles Institute of Neuroscience John Curtin School of Medical Research Australian National University  Canberra Australian Capital Territory 2601 Australia"},{"name":"School of Medical Sciences University of New South Wales  Sydney New South Wales 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Maddess","sequence":"additional","affiliation":[{"name":"The Eccles Institute of Neuroscience John Curtin School of Medical Research Australian National University  Canberra Australian Capital Territory 2601 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Redmond","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Engineering University of New South Wales  Sydney New South Wales 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Morley","sequence":"additional","affiliation":[{"name":"School of Medicine Western Sydney University  Sydney New South Wales 2560 Australia"},{"name":"School of Medical Sciences University of New South Wales  Sydney New South Wales 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg J.","family":"Stuart","sequence":"additional","affiliation":[{"name":"The Eccles Institute of Neuroscience John Curtin School of Medical Research Australian National University  Canberra Australian Capital Territory 2601 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-8211","authenticated-orcid":false,"given":"Jason R.","family":"Potas","sequence":"additional","affiliation":[{"name":"The Eccles Institute of Neuroscience John Curtin School of Medical Research Australian National University  Canberra Australian Capital Territory 2601 Australia"},{"name":"School of Medical Sciences University of New South Wales  Sydney New South Wales 2052 Australia"},{"name":"ANU Medical School Australian National University  Canberra Australian Capital Territory 2601 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3229-05.2005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1964.27.6.1096"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1964.27.1.92"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1964.27.1.78"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011413"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237348"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056630"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-1305-8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3241"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1523\/JNEUROSCI.09-09-03146.1989","article-title":"Postsynaptic dorsal column pathway of the rat. 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