{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:05:44Z","timestamp":1790694344355,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["275954"],"award-info":[{"award-number":["275954"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["284155"],"award-info":[{"award-number":["284155"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["286384"],"award-info":[{"award-number":["286384"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["139767"],"award-info":[{"award-number":["139767"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2017,7,15]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Dentate spikes are fast fluctuations of hilar local\u2010field potentials that take place during rest and are thought to reflect input arriving from the entorhinal cortex to the hippocampus.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>During dentate spikes, neuronal firing in hippocampal input (dentate gyrus) and output (CA1\/CA3) regions is uncoupled.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>To date, the behavioural significance of dentate spikes is unknown.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Here, we provide evidence that disrupting the dentate spike\u2010related uncoupling of the dentate gyrus and the CA1\/CA3 subregions for 1\u00a0h after training retards associative learning.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We suggest dentate spikes play a significant role in memory consolidation.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Hippocampal electrophysiological oscillations, namely theta and ripples, have been implicated in encoding and consolidation of new memories, respectively. According to existing literature, hippocampal dentate spikes are prominent, short\u2010duration (&lt;30\u00a0ms), large\u2010amplitude (\u223c2\u20134\u00a0mV) fluctuations in hilar local\u2010field potentials that take place during awake immobility and sleep. Interestingly, previous studies indicate that during dentate spikes dentate gyrus granule cells increase their firing while firing of CA1 pyramidal cells are suppressed, thus resulting in momentary uncoupling of the two hippocampal subregions. To date, the behavioural significance of dentate spikes is unknown. Here, to study the possible role of dentate spikes in learning, we trained adult male Sprague\u2013Dawley rats in trace eyeblink classical conditioning. For 1\u00a0h immediately following each conditioning session, one group of animals received hippocampal stimulation via the ventral hippocampal commissure (vHC) contingent on dentate spikes to disrupt the uncoupling between the dentate gyrus and the CA1 subregions. A yoked control group was stimulated during immobility, irrespective of brain state, and another control group was not stimulated at all. As a result, learning was impaired only in the group where vHC stimulation was administered contingent on dentate spikes. Our results suggest dentate spikes and\/or the associated uncoupling of the dentate gyrus and the CA1 play a significant role in memory consolidation. Dentate spikes could possibly reflect reactivation and refinement of a memory trace within the dentate gyrus triggered by input from the entorhinal cortex.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp274023","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T14:04:39Z","timestamp":1492697079000},"page":"4961-4971","source":"Crossref","is-referenced-by-count":38,"title":["Hippocampal electrical stimulation disrupts associative learning when targeted at dentate spikes"],"prefix":"10.1113","volume":"595","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-6118","authenticated-orcid":false,"given":"Miriam S.","family":"Nokia","sequence":"first","affiliation":[{"name":"Department of Psychology University of Jyv\u00e4skyl\u00e4  PO Box 35 FI\u201040014 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Gureviciene","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Jyv\u00e4skyl\u00e4  PO Box 35 FI\u201040014 Finland"},{"name":"University of Eastern Finland A.I.Virtanen Institute for Molecular Sciences  PO Box 1627 FI\u201070211 Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomi","family":"Waselius","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Jyv\u00e4skyl\u00e4  PO Box 35 FI\u201040014 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Tanila","sequence":"additional","affiliation":[{"name":"University of Eastern Finland A.I.Virtanen Institute for Molecular Sciences  PO Box 1627 FI\u201070211 Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Penttonen","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Jyv\u00e4skyl\u00e4  PO Box 35 FI\u201040014 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