{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:29:34Z","timestamp":1759937374522,"version":"3.41.0"},"reference-count":63,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T00:00:00Z","timestamp":1489104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB665, SPP1608,SFB885"],"award-info":[{"award-number":["SFB665, SPP1608,SFB885"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\"><jats:list-item><jats:p>Chronic perinatal nicotine exposure causes abnormal auditory brainstem responses and auditory processing deficits in children and animal models.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>The effect of perinatal nicotine exposure on synaptic maturation in the auditory brainstem was investigated in granule cells in the ventral nucleus of the lateral lemniscus, which receive a single calyx\u2010like input from the cochlear nucleus.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Perinatal nicotine exposure caused a massive reduction in the amplitude of the excitatory input current.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>This caused a profound decrease in the number and temporal precision of spikes in these neurons.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Perinatal nicotine exposure delayed the developmental downregulation of functional nicotinic acetylcholine receptors on these neurons.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Maternal smoking causes chronic nicotine exposure during early development and results in auditory processing deficits including delayed speech development and learning difficulties. Using a mouse model of chronic, perinatal nicotine exposure we explored to what extent synaptic inputs to granule cells in the ventral nucleus of the lateral lemniscus are affected by developmental nicotine treatment. These neurons receive one large calyx\u2010like input from octopus cells in the cochlear nucleus and play a role in sound pattern analysis, including speech sounds. In addition, they exhibit high levels of \u03b17 nicotinic acetylcholine receptors, especially during early development. Our whole\u2010cell patch\u2010clamp experiments show that perinatal nicotine exposure causes a profound reduction in synaptic input amplitude. In contrast, the number of inputs innervating each neuron and synaptic release properties of this calyx\u2010like synapse remained unaltered. Spike number and spiking precision in response to synaptic stimulation were greatly diminished, especially for later stimuli during a stimulus train. Moreover, chronic nicotine exposure delayed the developmental downregulation of functional nicotinic acetylcholine receptors on these neurons, indicating a direct action of nicotine in this brain area. This presumably direct effect of perinatal nicotine exposure on synaptic maturation in the auditory brainstem might be one of the underlying causes for auditory processing difficulties in children of heavy smoking mothers.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp274059","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T00:52:59Z","timestamp":1486947179000},"page":"3573-3590","source":"Crossref","is-referenced-by-count":17,"title":["Perinatal nicotine exposure impairs the maturation of glutamatergic inputs in the auditory brainstem"],"prefix":"10.1113","volume":"595","author":[{"given":"Veronika J.","family":"Baumann","sequence":"first","affiliation":[{"name":"Institute of Biology, Neurophysiology Freie Universit\u00e4t Berlin 14195 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7550-1622","authenticated-orcid":false,"given":"Ursula","family":"Koch","sequence":"additional","affiliation":[{"name":"Institute of Biology, Neurophysiology Freie Universit\u00e4t Berlin 14195 Berlin Germany"},{"name":"NeuroCure Cluster of Excellence Charit\u00e9 Universit\u00e4tsmedizin Charit\u00e9platz 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.12.049"},{"key":"e_1_2_6_3_1","first-page":"335","article-title":"Projections from octopus cells of the posteroventral cochlear nuceus to the ventral nucleus of the lateral lemniscus in cat and human","volume":"3","author":"Adams JC","year":"1997","journal-title":"Aud Neurosci"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0026-895X(25)09068-6","article-title":"Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist","volume":"41","author":"Alkondon M","year":"1992","journal-title":"Mol Pharmacol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-16-06106.2000"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3664-13.2014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1523\/JNEUROSCI.21-06-01819.2001","article-title":"Chronic exposure to nicotine upregulates the human \u03b14\u03b22 nicotinic acetylcholine receptor function","volume":"21","author":"Buisson B","year":"2001","journal-title":"J\u00a0Neurosci"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2015.00074"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00474.2010"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.04.001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5112-10.2011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901970409"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-04-03138.1995"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.05.024"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270818"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2795-13.2014"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2004.07.004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00355.2007"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.03.002"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.975308"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22318"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2009.02.002"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00526.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9521"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1015"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5433-10.2011"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04945.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.05.022"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3285-09.2009"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6246-11.2012"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(94)90048-5"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00084-3"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195320"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-004-5015-4"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20753"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00167.2005"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21058"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.61.1.497"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3654-0_6"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2004.05.009"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016340903511068"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00876.2010"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.03.083"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00408.2014"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00971.2011"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902130408"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1986.56.2.261"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1111"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2743-11.2011"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90698-B"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971215)389:2<264::AID-CNE6>3.0.CO;2-#"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970317)379:3<363::AID-CNE4>3.0.CO;2-1"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.08.005"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050818"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126500"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2008.08.009"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14099"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009058"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80756-4"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01087.2010"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.04.069"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4299-14.2015"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1041-12.2012"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FJP274059","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP274059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T08:25:25Z","timestamp":1749975925000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP274059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,10]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1113\/JP274059"],"URL":"https:\/\/doi.org\/10.1113\/jp274059","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"type":"print","value":"0022-3751"},{"type":"electronic","value":"1469-7793"}],"subject":[],"published":{"date-parts":[[2017,3,10]]}}}