{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:53:37Z","timestamp":1789718017690,"version":"4.0.1"},"reference-count":73,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,3]],"date-time":"2017-12-03T00:00:00Z","timestamp":1512259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["189374\/V40"],"award-info":[{"award-number":["189374\/V40"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2018,1,15]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Spinal compression injury targeted to the neonatal upper lumbar spinal cord, the region of highest hindlimb locomotor rhythmogenicity, leads to an initial paralysis of the hindlimbs.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Behavioural recovery is evident within a few days and approaches normal function within about 3\u00a0weeks.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Fictive locomotion in the isolated injured spinal cord cannot be elicited by a neurochemical cocktail containing NMDA, dopamine and serotonin 1\u00a0day post\u2010injury, but can 3\u00a0days post\u2010injury as readily as in the uninjured spinal cord.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Low frequency coordinated rhythmic activity can be elicited in the isolated uninjured spinal cord by NMDA + dopamine (without serotonin), but not in the isolated injured spinal cord.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In both the injured and uninjured spinal cord, eliciting bona fide fictive locomotion requires the additional presence of serotonin.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Following incomplete compression injury in the thoracic spinal cord of neonatal mice 1\u00a0day after birth (P1), we previously reported that virtually normal hindlimb locomotor function is recovered within about 3\u00a0weeks despite substantial permanent thoracic tissue loss. Here, we asked whether similar recovery occurs following lumbar injury that impacts more directly on the locomotor central pattern generator (CPG). As in thoracic injuries, lumbar injuries caused about 90% neuronal loss at the injury site and increased serotonergic innervation below the injury. Motor recovery was slower after lumbar than thoracic injury, but virtually normal function was attained by P25 in both cases. Locomotor CPG status was tested by eliciting fictive locomotion in isolated spinal cords using a widely used neurochemical cocktail (NMDA, dopamine, serotonin). No fictive locomotion could be elicited 1\u00a0day post\u2010injury, but could within 3\u00a0days post\u2010injury as readily as in age\u2010matched uninjured control spinal cords. Burst patterning and coordination were largely similar in injured and control spinal cords but there were differences. Notably, in both groups there were two main locomotor frequencies, but injured spinal cords exhibited a shift towards the higher frequency. Injury also altered the neurochemical dependence of locomotor CPG output, such that injured spinal cords, unlike control spinal cords, were incapable of generating low frequency rhythmic coordinated activity in the presence of NMDA and dopamine alone. Thus, the neonatal spinal cord also exhibits remarkable functional recovery after lumbar injuries, but the neurochemical sensitivity of locomotor circuitry is modified in the process.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp274484","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T09:22:39Z","timestamp":1509441759000},"page":"281-303","source":"Crossref","is-referenced-by-count":19,"title":["Rapid recovery and altered neurochemical dependence of locomotor central pattern generation following lumbar neonatal spinal cord injury"],"prefix":"10.1113","volume":"596","author":[{"given":"Mark","family":"Z\u00fcchner","sequence":"first","affiliation":[{"name":"Laboratory of Neural Development and Optical Recording (NDEVOR), Division of Physiology, Department of Molecular Medicine University of Oslo  Oslo Norway"},{"name":"Norwegian Centre for Stem Cell Research Oslo University Hospital  Oslo Norway"},{"name":"Department of Neurosurgery Oslo University 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