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Participants performed three randomly ordered trials of 70\u00b0 upright back\u2010supported dynamic leg cycling after ingestion of placebo and two different lipid soluble angiotensin converting enzyme inhibitors (ACEi): perindopril (high lipid solubility), captopril (low lipid solubility). Repeated measurements of whole venous blood (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), MSNA (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) and arterial blood pressures (<jats:italic>n<\/jats:italic>\u00a0=\u00a014) were obtained at rest and during an acute (SS1) and prolonged (SS2) bout of steady state dynamic exercise. Arterial baroreflex function curves were modelled at rest and during exercise. Peripheral venous superoxide concentrations measured by electron spin resonance spectroscopy were elevated during exercise and were not altered by ACEi at rest (<jats:italic>P<\/jats:italic>\u00a0\u2265\u00a00.4) or during exercise (<jats:italic>P<\/jats:italic>\u00a0\u2265\u00a00.3). Baseline MSNA and mean arterial pressure were unchanged at rest (<jats:italic>P<\/jats:italic>\u00a0\u2265\u00a00.1; <jats:italic>P<\/jats:italic>\u00a0\u2265\u00a00.8, respectively). However, during both SS1 and SS2, the centrally acting ACEi perindopril attenuated MSNA compared to captopril and the placebo (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Arterial pressures at the operating point and threshold pressures were decreased with perindopril from baseline to SS1 with no further changes in the operating point pressure during SS2 under all three conditions. These data suggest that centrally acting ACEi is significantly more effective at attenuating the increase in the acute and prolonged exercise\u2010induced increases in MSNA.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp274697","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:23:03Z","timestamp":1523406183000},"page":"2315-2332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of centrally acting angiotensin converting enzyme inhibitor on the exercise\u2010induced increases in muscle sympathetic nerve activity"],"prefix":"10.1113","volume":"596","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-2383","authenticated-orcid":false,"given":"Gilbert","family":"Moralez","sequence":"first","affiliation":[{"name":"Institute for Cardiovascular and Metabolic Disease University of North Texas Health Science Center  Fort Worth TX USA"},{"name":"Institute for Exercise and 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