{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:46:42Z","timestamp":1790264802576,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["08\/088A"],"award-info":[{"award-number":["08\/088A"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["09\/095"],"award-info":[{"award-number":["09\/095"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Fetal growth restriction increases the risk of fetal and neonatal mortality and morbidity, and contributes to increased risk of chronic disease later in life.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intra\u2010amniotic insulin\u2010like growth factor\u20101 (IGF1) treatment of the growth\u2010restricted ovine fetus improves fetal growth, but postnatal effects are unknown.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Here we report that intra\u2010amniotic IGF1 treatment of the growth\u2010restricted ovine fetus alters size at birth and mechanisms of early postnatal growth in a sex\u2010specific manner.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We also show that maternal plasma C\u2010type natriuretic peptide (CNP) products are related to fetal oxygenation and size at birth, and hence may be useful for non\u2010invasive monitoring of fetal growth restriction.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intrauterine IGF1 treatment in late gestation is a potentially clinically relevant intervention that may ameliorate the postnatal complications of fetal growth restriction.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Placental insufficiency\u2010mediated fetal growth restriction (FGR) is associated with altered postnatal growth and metabolism, which are, in turn, associated with increased risk of adult disease. Intra\u2010amniotic insulin\u2010like growth factor\u20101 (IGF1) treatment of ovine FGR increases growth rate in late gestation, but the effects on postnatal growth and metabolism are unknown. We investigated the effects of intra\u2010amniotic IGF1 administration to ovine fetuses with uteroplacental embolisation\u2010induced FGR on phenotypical and physiological characteristics in the 2\u00a0 weeks after birth. We measured early postnatal growth velocity, amino\u2010terminal propeptide of C\u2010type natriuretic peptide (NTproCNP), body composition, tissue\u2010specific mRNA expression, and milk intake in singleton lambs treated weekly with 360\u00a0\u03bcg intra\u2010amniotic IGF1 (FGRI; <jats:italic>n\u00a0=\u00a0<\/jats:italic>13 females, 19 males) or saline (FGRS; <jats:italic>n\u00a0=\u00a0<\/jats:italic>18 females, 12 males) during gestation, and in controls (CON; <jats:italic>n\u00a0=\u00a0<\/jats:italic>15 females, 22 males). There was a strong positive correlation between maternal NTproCNP and fetal oxygenation, and size at birth in FGR lambs. FGR lambs were \u223c20% lighter at birth and demonstrated accelerated postnatal growth velocity. IGF1 treatment did not alter perinatal mortality, partially abrogated the reduction in newborn size in females, but not males, and reduced accelerated growth in both sexes. IGF1\u2010mediated upregulation of somatotrophic genes in males during the early postnatal period could suggest that treatment effects are associated with delayed axis maturation, whilst treatment outcomes in females may rely on the reprogramming of nutrient\u2010dependent mechanisms of growth. These data suggest that the growth\u2010restricted fetus is responsive to intra\u2010amniotic intervention with IGF1, and that sex\u2010specific somatotrophic effects persist in the early postnatal period.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp274999","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T04:09:41Z","timestamp":1513138181000},"page":"5925-5945","source":"Crossref","is-referenced-by-count":25,"title":["Postnatal effects of intrauterine treatment of the growth\u2010restricted ovine fetus with intra\u2010amniotic insulin\u2010like growth factor\u20101"],"prefix":"10.1113","volume":"596","author":[{"given":"A. M.","family":"Spiroski","sequence":"first","affiliation":[{"name":"The Liggins Institute University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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