{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:47:54Z","timestamp":1784933274075,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["FEM2015\u201063631\u2010R"],"award-info":[{"award-number":["FEM2015\u201063631\u2010R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Intrauterine growth restriction (IUGR), induced by maternal undernutrition, leads to impaired aortic development. This is followed by hypertrophic remodelling associated with accelerated growth during lactation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Fetal nutrient restriction is associated with increased aortic compliance at birth and at weaning, but not in adult animals. This mechanical alteration may be related to a decreased perinatal collagen deposition.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Aortic elastin scaffolds purified from young male and female IUGR animals also exhibit increased compliance, only maintained in adult IUGR females. These mechanical alterations may be related to differences in elastin deposition and remodelling.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Fetal undernutrition induces similar aortic structural and mechanical alterations in young male and female rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our data argue against an early mechanical cause for the sex differences in hypertension development induced by maternal undernutrition. However, the larger compliance of elastin in adult IUGR females may contribute to the maintenance of a normal blood pressure level.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Fetal undernutrition programmes hypertension development, males being more susceptible. Deficient fetal elastogenesis and vascular growth is a possible mechanism. We investigated the role of aortic mechanical alterations in a rat model of hypertension programming, evaluating changes at birth, weaning and adulthood. Dams were fed <jats:italic>ad libitum<\/jats:italic> (Control) or 50% of control intake during the second half of gestation (maternal undernutrition, MUN). Offspring aged 3\u00a0days, 21\u00a0days and 6\u00a0months were studied. Blood pressure was evaluated <jats:italic>in vivo<\/jats:italic>. In the thoracic aorta we assessed gross structure, mechanical properties (intact and purified elastin), collagen and elastin content and internal elastic lamina (IEL) organization. Only adult MUN males developed hypertension (systolic blood pressure: MUN<jats:sub>males<\/jats:sub>\u00a0=\u00a0176.6\u00a0\u00b1\u00a05.6\u00a0mmHg; Control<jats:sub>males<\/jats:sub>\u00a0=\u00a0136.1\u00a0\u00b1\u00a04.9\u00a0mmHg). At birth MUN rats were lighter, with smaller aortic cross\u2010sectional area (MUN<jats:sub>males<\/jats:sub>\u00a0=\u00a0(1.51\u00a0\u00b1\u00a00.08)\u00a0\u00d7\u00a010<jats:sup>5<\/jats:sup>\u00a0\u03bcm<jats:sup>2<\/jats:sup>, Control<jats:sub>males<\/jats:sub>\u00a0=\u00a0(2.8\u00a0\u00b1\u00a00.04)\u00a0\u00d7\u00a010<jats:sup>5<\/jats:sup>\u00a0\u03bcm<jats:sup>2<\/jats:sup>); during lactation MUN males and females exhibited catch\u2010up growth and aortic hypertrophy (MUN<jats:sub>males<\/jats:sub>\u00a0=\u00a0(14.5\u00a0\u00b1\u00a00.5)\u00a0\u00d7\u00a010<jats:sup>5<\/jats:sup>\u00a0\u03bcm<jats:sup>2<\/jats:sup>, Control<jats:sub>males<\/jats:sub>\u00a0=\u00a0(10.4\u00a0\u00b1\u00a00.9)\u00a0\u00d7\u00a010<jats:sup>5<\/jats:sup>\u00a0\u03bcm<jats:sup>2<\/jats:sup>), maintained until adulthood. MUN aortas were more compliant until weaning (functional stiffness: MUN<jats:sub>males<\/jats:sub>\u00a0=\u00a01.0\u00a0\u00b1\u00a00.04; Control<jats:sub>males<\/jats:sub>\u00a0=\u00a01.3\u00a0\u00b1\u00a00.03), containing less collagen with larger IEL fenestrae, returning to normal in adulthood. Purified elastin from young MUN offspring was more compliant in both sexes; only MUN adult females maintained larger elastin compliance (slope: MUN<jats:sub>females<\/jats:sub>\u00a0=\u00a024.1\u00a0\u00b1\u00a01.9; Control<jats:sub>females<\/jats:sub>\u00a0=\u00a033.3\u00a0\u00b1\u00a02.8). Fetal undernutrition induces deficient aortic development followed by hypertrophic remodelling and larger aortic compliance in the perinatal period, with similar alterations in collagen and elastin in both sexes. The observed alterations argue against an initial mechanical cause for sex differences in hypertension development. However, the maintenance of high elastin compliance in adult females might protect them against blood pressure rise.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp275030","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T05:52:37Z","timestamp":1514267557000},"page":"5791-5806","source":"Crossref","is-referenced-by-count":18,"title":["Role of fetal nutrient restriction and postnatal catch\u2010up growth on structural and mechanical alterations of rat aorta"],"prefix":"10.1113","volume":"596","author":[{"given":"Perla Y.","family":"Guti\u00e9rrez\u2010Arzapalo","sequence":"first","affiliation":[{"name":"Department of Physiology Universidad Aut\u00f3noma de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Rodr\u00edguez\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Physiology Universidad Aut\u00f3noma de Madrid  Madrid 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