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Using ultrasound, we determined regional blood flow, blood vessel sizes, and distensibility in IUGR baboons (8 males, 8 females, 8.8\u00a0years, similar to 35 human years) and controls (12 males, 12 females, 9.5\u00a0years). The measured blood vessels were larger in size in the males compared to females before but not after normalization to body surface area. Smaller IUGR normalized blood vessel sizes were observed in the femoral and external iliac arteries but not the brachial or common carotid arteries and not correlated significantly with birth weight. Mild decrease in distensibility in the IUGR group was seen in the iliac but not the carotid arteries without between\u2010sex differences. In IUGR baboons there was increased carotid arterial blood flow velocity during late systole and diastole. Overall, our findings support the conclusion that region specific vascular and haemodynamic changes occur with IUGR, which may contribute to the occurrence of later life cardiac dysfunction. The pattern of alteration observed suggests vascular redistribution efforts in response to challenges in the perinatal period may persist into adulthood. Further studies are needed to determine the life course progression of these changes.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp275139","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T12:52:03Z","timestamp":1509713523000},"page":"5777-5790","source":"Crossref","is-referenced-by-count":31,"title":["Intrauterine growth restriction results in persistent vascular mismatch in adulthood"],"prefix":"10.1113","volume":"596","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5517-7984","authenticated-orcid":false,"given":"Anderson H.","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Radiology and Research Imaging Institute University of Texas Health Science Center at San Antonio  San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Animal Science University of Wyoming  Laramie WY USA"},{"name":"Southwest National Primate Research Center  San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-427X","authenticated-orcid":false,"given":"Hillary F.","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Animal Science University of Wyoming  Laramie WY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4559-6437","authenticated-orcid":false,"given":"Geoffrey D.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Imaging Institute University of Texas Health Science Center at San Antonio  San Antonio TX USA"},{"name":"Southwest National Primate Research Center  San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Nathanielsz","sequence":"additional","affiliation":[{"name":"Department of Animal Science University of Wyoming  Laramie WY USA"},{"name":"Southwest National Primate Research Center  San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.06.044"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(97)00202-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.072009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00591.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.4.1165"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"The growth and development of the rat aorta. 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