{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:43:08Z","timestamp":1790678588996,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL\u2010103786"],"award-info":[{"award-number":["HL\u2010103786"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL\u2010116579"],"award-info":[{"award-number":["HL\u2010116579"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["E1572P"],"award-info":[{"award-number":["E1572P"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2018,4,15]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We investigated the contribution of group III\/IV muscle afferents to carotid baroreflex resetting during electrically evoked (no central command) and voluntary (requiring central command) isometric knee extension exercise.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Lumbar intrathecal fentanyl was used to attenuate the central projection of \u03bc\u2010opioid receptor\u2010sensitive group III\/IV leg muscle afferent feedback. Spontaneous carotid baroreflex control was assessed by loading and unloading the carotid baroreceptors with a variable pressure neck chamber.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Group III\/IV muscle afferents did not influence spontaneous carotid baroreflex responsiveness at rest or during exercise.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Afferent feedback accounted for at least 50% of the exercise\u2010induced increase in the carotid baroreflex blood pressure and heart rate operating points, adjustments that are critical for an appropriate cardiovascular response to exercise.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These findings suggest that group III\/IV muscle afferent feedback is, independent of central command, critical for the resetting of the carotid baroreflex blood pressure and heart rate operating points, but not for spontaneous baroreflex responsiveness.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>This study sought to comprehensively investigate the role of metabolically and mechanically sensitive group III\/IV muscle afferents in carotid baroreflex responsiveness and resetting during both electrically evoked (EVO, no central command) and voluntary (VOL, requiring central command) isometric single\u2010leg knee\u2010extension (15% of maximal voluntary contraction; MVC) exercise. Participants (<jats:italic>n\u00a0=\u00a0<\/jats:italic>8) were studied under control conditions (CTRL) and following lumbar intrathecal fentanyl injection (FENT) to inhibit \u03bc\u2010opioid receptor\u2010sensitive lower limb muscle afferents. Spontaneous carotid baroreflex control of mean arterial pressure (MAP) and heart rate (HR) were assessed following rapid 5\u00a0s pulses of neck pressure (NP, +40\u00a0mmHg) or suction (NS, \u221260\u00a0mmHg). Resting MAP (87\u00a0\u00b1\u00a010\u00a0mmHg) and HR (70\u00a0\u00b1\u00a08\u00a0bpm) were similar between CTRL and FENT conditions (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.4). In terms of spontaneous carotid baroreflex responsiveness, FENT did not alter the change in MAP or HR responses to NP (+13\u00a0\u00b1\u00a05\u00a0mmHg, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.85; +9\u00a0\u00b1\u00a03\u00a0bpm; <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.99) or NS (\u221213\u00a0\u00b1\u00a05\u00a0mmHg, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.99; \u221224\u00a0\u00b1\u00a011\u00a0bpm; <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.49) at rest or during either exercise protocol, which were of a remarkably similar magnitude to rest. In contrast, FENT administration\u00a0reduced the exercise\u2010induced resetting of the operating point for MAP and HR during both EVO (116\u00a0\u00b1\u00a010\u00a0mmHg to 100\u00a0\u00b1\u00a015\u00a0mmHg and 93\u00a0\u00b1\u00a014\u00a0bpm to 82\u00a0\u00b1\u00a010\u00a0bpm) and VOL (107\u00a0\u00b1\u00a013\u00a0mmHg to 100\u00a0\u00b1\u00a017\u00a0mmHg and 89\u00a0\u00b1\u00a010\u00a0bpm to 72\u00a0\u00b1\u00a010\u00a0bpm) exercise bouts. Together, these findings document that group III\/IV muscle afferent feedback is critical for the resetting of the carotid baroreflex MAP and HR operating points, independent of exercise\u2010induced changes in central command, but not for spontaneous carotid baroreflex responsiveness.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp275465","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T07:56:41Z","timestamp":1517471801000},"page":"1373-1384","source":"Crossref","is-referenced-by-count":41,"title":["Identifying the role of group III\/IV muscle afferents in the carotid baroreflex control of mean arterial pressure and heart rate during exercise"],"prefix":"10.1113","volume":"596","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-5723","authenticated-orcid":false,"given":"Thomas J.","family":"Hureau","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Utah  Salt Lake City UT USA"},{"name":"Geriatric Research Education, and Clinical Center, Salt Lake City VA Medical Center  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Weavil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah  Salt Lake City UT USA"},{"name":"Geriatric Research Education, and Clinical Center, Salt Lake City VA Medical Center  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor S.","family":"Thurston","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7388-2214","authenticated-orcid":false,"given":"Ryan M.","family":"Broxterman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah  Salt Lake City UT USA"},{"name":"Geriatric Research Education, and Clinical Center, Salt Lake City VA Medical Center  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley D.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber D.","family":"Bledsoe","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E.","family":"Jessop","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell S.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah  Salt Lake City UT USA"},{"name":"Geriatric Research Education, and Clinical Center, Salt Lake City VA Medical Center  Salt Lake City UT USA"},{"name":"Department of Nutrition and Integrative Physiology University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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