{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:23:17Z","timestamp":1783995797150,"version":"3.55.0"},"reference-count":56,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FS 154313"],"award-info":[{"award-number":["FS 154313"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 133675"],"award-info":[{"award-number":["MOP 133675"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Advanced maternal age increases the risk of pregnancy complications such as fetal growth restriction, hypertension and premature birth.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Offspring born from compromised pregnancies are at increased risk of cardiovascular disease as adults. However, the effect of advanced maternal age on later\u2010onset disease in offspring has not been investigated.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In adulthood, male but not female offspring born to dams of advanced maternal age showed impaired recovery from cardiac ischaemia\/reperfusion injury.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Endothelium\u2010dependent relaxation was also impaired in male but not female offspring born from aged dams.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Oxidative stress may play a role in the developmental programming of cardiovascular disease in this model.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Given the increasing trend toward delayed parenthood, these findings have significant population and health care implications and warrant further investigation.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Exposure to prenatal stressors, including hypoxia, micro\u2010 and macronutrient deficiency, and maternal stress, increases the risk of cardiovascular disease in adulthood. It is unclear whether being born from a mother of advanced maternal age (\u226535\u00a0years old) may also constitute a prenatal stress with cardiovascular consequences in adulthood. We previously demonstrated growth restriction in fetuses from a rat model of advanced maternal age, suggesting exposure to a compromised <jats:italic>in utero<\/jats:italic> environment. Thus, we hypothesized that male and female offspring from aged dams would exhibit impaired cardiovascular function as adults. In 4\u2010month\u2010old offspring, we observed impaired endothelium\u2010dependent relaxation in male (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) but not female offspring born from aged dams. The anti\u2010oxidant polyethylene glycol superoxide dismutase improved relaxation only in arteries from male offspring of aged dams (\u0394<jats:italic>E<\/jats:italic><jats:sub>max<\/jats:sub>: young dam \u20131.63\u00a0\u00b1\u00a00.80\u00a0<jats:italic>vs<\/jats:italic>. aged dam 11.75\u00a0\u00b1\u00a04.23, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Furthermore, endothelium\u2010derived hyperpolarization\u2010dependent relaxation was reduced in male but not female offspring of aged dams (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Interestingly, there was a significant increase in nitric oxide contribution to relaxation in females born from aged dams (\u0394<jats:italic>E<\/jats:italic><jats:sub>max<\/jats:sub>: young dam \u201324.8\u00a0\u00b1\u00a012.1\u00a0<jats:italic>vs<\/jats:italic>. aged dam \u201368.7\u00a0\u00b1\u00a07.7, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), which was not observed in males. Recovery of cardiac function following an ischaemia\u2010reperfusion insult in male offspring born from aged dams was reduced by \u223c57% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), an effect that was not evident in female offspring. These data indicate that offspring born from aged dams have an altered cardiovascular risk profile that is sex\u2010specific. Given the increasing trend toward delaying pregnancy, these findings may have significant population and health care implications and warrant further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp275472","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T01:15:56Z","timestamp":1528420556000},"page":"5807-5821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Increased susceptibility to cardiovascular disease in offspring born from dams of advanced maternal age"],"prefix":"10.1113","volume":"596","author":[{"given":"Christy\u2010Lynn M.","family":"Cooke","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Alberta  Edmonton Alberta Canada"},{"name":"Women and Children's Health Research Institute University of Alberta  Edmonton Alberta Canada"},{"name":"Lois Hole Hospital for Women  Edmonton Alberta 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