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Oxygen saturation (oxymetry), mean arterial pressure (photoplethysmography) and muscle sympathetic nerve activity (MSNA; microneugraphy), as well as femoral artery (FA), internal carotid artery and vertebral artery (VA) blood flow (BF; Doppler ultrasound), were quantified in nine normotensive (NT) (aged 40\u00a0\u00b1\u00a011\u00a0years, systolic pressure 119\u00a0\u00b1\u00a07\u00a0mmHg and diastolic pressure 73\u00a0\u00b1\u00a06\u00a0mmHg) and nine hypertensive men (HT) (aged 44\u00a0\u00b1\u00a012\u00a0years, systolic pressure 152\u00a0\u00b1\u00a011\u00a0mmHg and diastolic pressure 90\u00a0\u00b1\u00a09\u00a0mmHg) during 5\u00a0min of normoxia (21% O<jats:sub>2<\/jats:sub>) and IH (10% O<jats:sub>2<\/jats:sub>). Total cerebral blood flow (tCBF), brain (CDO<jats:sub>2<\/jats:sub>) and leg (LDO<jats:sub>2<\/jats:sub>) oxygen delivery were estimated. IH provoked similar oxygen desaturation without changing mean arterial pressure. Internal carotid artery perfusion increased in both groups during IH. However, VA and FA BF only increased in NT. Thus, IH\u2010induced increase in tCBF was smaller in HT. CDO<jats:sub>2<\/jats:sub> only increased in NT and LDO<jats:sub>2<\/jats:sub> decreased in HT. Furthermore, IH evoked a greater increase in HT MSNA. Changes in MSNA were inversely related to FA BF, LDO<jats:sub>2<\/jats:sub> and end\u2010tidal oxygen tension. In conclusion, hypertension disturbs regional and total cerebrovascular and peripheral responses to IH and consequently limits oxygen supply to the brain and skeletal muscle. Although increased chemoreflex\u2010induced sympathetic activation may explain impaired peripheral perfusion, attenuated vasodilatory signalling in the posterior cerebrovasculature appears to be responsible for the small increase in tCBF when HT were exposed to IH.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp275545","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T20:02:14Z","timestamp":1519243334000},"page":"1167-1179","source":"Crossref","is-referenced-by-count":33,"title":["Reduced arterial vasodilatation in response to hypoxia impairs cerebral and peripheral oxygen delivery in hypertensive men"],"prefix":"10.1113","volume":"596","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3873-2656","authenticated-orcid":false,"given":"Igor A.","family":"Fernandes","sequence":"first","affiliation":[{"name":"Laboratory of Exercise Sciences Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos P.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Sciences Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique O.","family":"Campos","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Sciences Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o D.","family":"Mattos","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Sciences Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Mansur","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Sciences Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena N. 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