{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:02:46Z","timestamp":1787508166402,"version":"build-2736575974"},"reference-count":72,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cooperative Research Centre for Alertness, Safety and Productivity, Melbourne, Victoria, Australia","award":["P2.1.01-15."],"award-info":[{"award-number":["P2.1.01-15."]}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Shift work is highly prevalent and is associated with significant adverse health impacts.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>There is substantial inter\u2010individual variability in the way the circadian clock responds to changing shift cycles. The mechanisms underlying this variability are not well understood.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We tested the hypothesis that light\u2013dark exposure is a significant contributor to this variability; when combined with diurnal preference, the relative timing of light exposure accounted for 71% of individual variability in circadian phase response to night shift work.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These results will drive development of personalised approaches to manage circadian disruption among shift workers and other vulnerable populations to potentially reduce the increased risk of disease in these populations.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Night shift workers show highly variable rates of circadian adaptation. This study examined the relationship between light exposure patterns and the magnitude of circadian phase resetting in response to night shift work. In 21 participants (nursing and medical staff in an intensive care unit) circadian phase was measured using 6\u2010sulphatoxymelatonin at baseline (day\/evening shifts or days off) and after 3\u20134 consecutive night shifts. Daily light exposure was examined relative to individual circadian phase to quantify light intensity in the phase delay and phase advance portions of the light phase response curve (PRC). There was substantial inter\u2010individual variability in the direction and magnitude of phase shift after three or four consecutive night shifts (mean phase delay \u22121:08\u00a0\u00b1\u00a01:31\u00a0h; range \u22123:43\u00a0h delay to +3:07\u00a0h phase advance). The relative difference in the distribution of light relative to the PRC combined with diurnal preference accounted for 71% of the variability in phase shift. Regression analysis incorporating these factors estimated phase shift to within \u00b160\u00a0min in 85% of participants. No participants met criteria for partial adaptation to night work after three or four consecutive night shifts. Our findings provide evidence that the phase resetting that does occur is based on individual light exposure patterns relative to an individual's baseline circadian phase. Thus, a \u2018one size fits all\u2019 approach to promoting adaptation to shift work using light therapy, implemented without knowledge of circadian phase, may not be efficacious for all individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp275589","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T09:55:03Z","timestamp":1522230903000},"page":"2381-2395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Temporal dynamics of circadian phase shifting response to consecutive night shifts in healthcare workers: role of light\u2013dark exposure"],"prefix":"10.1113","volume":"596","author":[{"given":"Julia E.","family":"Stone","sequence":"first","affiliation":[{"name":"Cooperative Research Centre for Alertness Safety and Productivity  Melbourne Victoria Australia"},{"name":"School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Faculty of Medicine, Nursing &amp; Health Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0005-7838","authenticated-orcid":false,"given":"Tracey L.","family":"Sletten","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Alertness Safety and Productivity  Melbourne Victoria Australia"},{"name":"School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Faculty of Medicine, Nursing &amp; Health Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Magee","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Alertness Safety and Productivity  Melbourne Victoria Australia"},{"name":"School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Faculty of Medicine, Nursing &amp; Health Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranea","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Alertness Safety and Productivity  Melbourne Victoria Australia"},{"name":"School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Faculty of Medicine, Nursing &amp; Health Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan D.","family":"Mulhall","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Alertness Safety and Productivity  Melbourne Victoria Australia"},{"name":"School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Faculty of Medicine, Nursing &amp; Health Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Collins","sequence":"additional","affiliation":[{"name":"Institute for Breathing and Sleep Austin Health  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Howard","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Alertness Safety and Productivity  Melbourne Victoria Australia"},{"name":"School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Faculty of Medicine, Nursing &amp; Health Sciences Monash University  Clayton Victoria Australia"},{"name":"Institute for Breathing and Sleep Austin Health  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Lockley","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Alertness Safety and Productivity  Melbourne Victoria Australia"},{"name":"School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Faculty of Medicine, Nursing &amp; Health Sciences Monash University  Clayton Victoria Australia"},{"name":"Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Division of Sleep Medicine Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7527-8558","authenticated-orcid":false,"given":"Shantha M. W.","family":"Rajaratnam","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Alertness Safety and Productivity  Melbourne Victoria Australia"},{"name":"School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Faculty of Medicine, Nursing &amp; Health Sciences Monash University  Clayton Victoria Australia"},{"name":"Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Division of Sleep Medicine Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456328802500319"},{"key":"e_1_2_5_3_1","volume-title":"Melatonin and the mammalian pineal gland","author":"Arendt J","year":"1995"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730405277492"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.6.R1598"},{"key":"e_1_2_5_6_1","first-page":"1423","article-title":"Learning to live on a Mars day: fatigue countermeasures during the Phoenix Mars Lander mission","volume":"35","author":"Barger LK","year":"2012","journal-title":"Sleep"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00965-8"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00585-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.155.3.341"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27083"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.675257"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730402238238"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/clinchem\/33.8.1343","article-title":"Melatonin secretion in humans assessed by measuring its metabolite, 6\u2010sulfatoxymelatonin","volume":"33","author":"Bojkowski CJ","year":"1987","journal-title":"Clin Chem"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070813"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730403253585"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15402010BSM0102_3"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(97)00298-5"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.226555"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2012.00998.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730403258422"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.6.1077"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2007.72.064"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)02147-7"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb03940.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010666108"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02427-2"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.115.4.895"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730405277983"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/074873001129002178"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2011.647177"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853899908998783"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36716"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12521"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apergo.2011.11.003"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520802106835"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5086"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00247-1"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730407302843"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)00051-J"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000741"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.699356"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520601100955"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-010-0547-x"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-015-1093-3"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/15.4.376"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1398"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.040477"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/28.10.1214"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030570"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.11.3763"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.10.004"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-120006080"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90856-O"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/074873049701200103"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2006.00532.x"},{"key":"e_1_2_5_58_1","first-page":"305","article-title":"Methods for cosinor\u2010rhythmometry","volume":"6","author":"Nelson W","year":"1979","journal-title":"Chronobiologia"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1987.tb01172.x"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4123"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06108-6"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)00018-E"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/15.5.434"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2010.07.002"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-73-2-227"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1990.tb00686.x"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2010.00137"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-9010.74.5.728"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.227892"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520802106850"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00223-4"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730404274265"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.201530198"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FJP275589","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP275589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:50:25Z","timestamp":1695491425000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP275589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,6]]},"references-count":72,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1113\/JP275589"],"URL":"https:\/\/doi.org\/10.1113\/jp275589","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,6]]},"assertion":[{"value":"2017-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}