{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:11:19Z","timestamp":1791576679113,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:00:00Z","timestamp":1523404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002181","name":"Lullaby Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1006647"],"award-info":[{"award-number":["APP1006647"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Periodic breathing and apnoea were more common in preterm compared to age\u2010matched term\u2010born infants across the first 6\u00a0months after term\u2010corrected age.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Periodic breathing decreased with age in both term and preterm infants.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Apnoea duration was not different between groups; however, the decline in apnoea index with postnatal age observed in the term infants was not seen in the preterm infants.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Falls in tissue oxygenation index (brain TOI) associated with apnoeas were greater in the preterm infants at all three ages studied.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The clinical significance of falls in brain TOI during periodic breathing and apnoea on neurodevelopmental outcome is unknown and warrants further investigations.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Periodic breathing and short apnoeas are common in infants, particularly those born preterm, but are thought to be benign. The aim of our study was to assess the incidence and impact of periodic breathing and apnoea on heart rate, oxygen saturation and brain tissue oxygenation index (TOI) in infants born at term and preterm over the first 6\u00a0months after term equivalent age. Nineteen term\u2010born infants (38\u201342\u00a0weeks gestational age) and 24 preterm infants (born at 27\u201336\u00a0weeks gestational age) were studied at 2\u20134\u00a0weeks, 2\u20133\u00a0months and 5\u20136\u00a0months post\u2010term\u2010corrected age during sleep. Periodic breathing episodes were defined as three or more sequential apnoeas each lasting \u22653\u00a0s and apnoeas as \u22653\u00a0s in duration. The mean duration of periodic breathing episodes was longer in term infants than in preterm infants at 2\u20134\u00a0weeks (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and at 5\u20136\u00a0months (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05); however, the nadir in TOI was significantly less in the term infants at 2\u20133\u00a0months (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Apnoea duration was not different between groups; however, the decline in apnoea index with postnatal age observed in the term infants was not seen in the preterm infants. Falls in TOI associated with apnoeas were greater in the preterm infants at all three ages studied. In conclusion, periodic breathing and short apnoeas were more common in infants born preterm and falls in cerebral oxygenation were greater than in the term group. The clinical significance of this on neurodevelopmental outcome is unknown and warrants further investigations.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp275686","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T13:22:34Z","timestamp":1520860954000},"page":"6021-6031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Comparison of the longitudinal effects of persistent periodic breathing and apnoea on cerebral oxygenation in term\u2010 and preterm\u2010born infants"],"prefix":"10.1113","volume":"596","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3575-0461","authenticated-orcid":false,"given":"Rosemary S. 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