{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:14:03Z","timestamp":1785831243920,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:00:00Z","timestamp":1523404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["106444"],"award-info":[{"award-number":["106444"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>The reason(s) for the increased central arterial stiffness in chronic obstructive pulmonary disease (COPD) are not well understood.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In this study, we inhibited the carotid chemoreceptor with both low\u2010dose dopamine and hyperoxia, and observed a decrease in central arterial stiffness and muscle sympathetic nervous activity in COPD patients, while no change was observed in age\u2010 and risk\u2010matched controls.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Carotid chemoreceptor inhibition increased vascular conductance, secondary to reduced arterial blood pressure in COPD patients.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Findings from the current study suggest that elevated carotid chemoreceptor activity may contribute to the increased arterial stiffness typically observed in COPD patients.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Chronic obstructive pulmonary disease (COPD) patients have increased central arterial stiffness and muscle sympathetic nervous activity (MSNA), both of which contribute to cardiovascular (CV) dysfunction and increased CV risk. Previous work suggests that COPD patients have elevated carotid chemoreceptor (CC) activity\/sensitivity, which may contribute to the elevated MSNA and arterial stiffness. Accordingly, the effect of CC inhibition on central arterial stiffness, MSNA and CV function at rest in COPD patients was examined in a randomized placebo\u2010controlled study. Thirteen mild\u2013moderate COPD patients (forced expired volume in 1 s (FEV<jats:sub>1<\/jats:sub>) predicted\u00a0\u00b1\u00a0SD: 83\u00a0\u00b1\u00a018%) and 13\u00a0age\u2010 and risk\u2010matched controls completed resting CV function measurements with either <jats:sc>i.v.<\/jats:sc> saline or <jats:sc>i.v.<\/jats:sc> dopamine (2\u00a0\u03bcg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0min<jats:sup>\u22121<\/jats:sup>) while breathing normoxic or hyperoxic air (100% O<jats:sub>2<\/jats:sub>). On a separate day, a subset of COPD patients and controls completed MSNA measurements while breathing normoxic or hyperoxic air. Arterial stiffness was determined by pulse\u2010wave velocity (PWV) and MSNA was measured by microneurography. Brachial blood flow was determined using Doppler ultrasound, cardiac output was estimated by impedance cardiography, and vascular conductance was calculated as flow\/mean arterial pressure (MAP). CC inhibition with dopamine decreased central and peripheral PWV, and MAP (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) while increasing vascular conductance in COPD. No change in CV function was observed with dopamine in controls. CC inhibition with hyperoxia decreased peripheral PWV and MSNA (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) in COPD, while no change was observed in controls. CC inhibition decreased PWV and MSNA, and improved vascular conductance in COPD, suggesting that tonic CC activity is elevated at rest and contributes to the elevated arterial stiffness in COPD.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp275762","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T09:22:43Z","timestamp":1520846563000},"page":"3233-3244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The carotid chemoreceptor contributes to the elevated arterial stiffness and vasoconstrictor outflow in chronic obstructive pulmonary disease"],"prefix":"10.1113","volume":"596","author":[{"given":"Devin B.","family":"Phillips","sequence":"first","affiliation":[{"name":"Division of Pulmonary Medicine, Faculty of Medicine and Dentistry University of Alberta  Edmonton Alberta Canada"},{"name":"Faculty of Physical Education and Recreation University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7190-7046","authenticated-orcid":false,"given":"Craig D.","family":"Steinback","sequence":"additional","affiliation":[{"name":"Faculty of Physical Education and Recreation University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie \u00c9.","family":"Collins","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Faculty of Medicine and Dentistry University of Alberta  Edmonton Alberta Canada"},{"name":"Faculty of Rehabilitation Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desi P.","family":"Fuhr","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Faculty of Medicine and Dentistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey L.","family":"Bryan","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Faculty of Medicine and Dentistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Y. 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