{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:00:40Z","timestamp":1778806840530,"version":"3.51.4"},"reference-count":78,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T00:00:00Z","timestamp":1534550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01\u2010DC004825"],"award-info":[{"award-number":["R01\u2010DC004825"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Dorsal cochlear nucleus fusiform cells receive spectrally relevant auditory input for sound localization.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Fusiform cells integrate auditory with other multisensory inputs.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Here we elucidate how somatosensory and vestibular stimulation modify the fusiform cell spatial code through activation of an inhibitory interneuron: the ventral cochlear nucleus D\u2010stellate cell.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results suggests that multisensory cues interact early in an ascending sensory pathway to serve an essential function.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>In the cochlear nucleus (CN), the first central site for coding sound location, numerous multisensory projections and their modulatory effects have been reported. However, multisensory influences on sound location processing in the CN remain unknown. The principal output neurons of the dorsal CN, fusiform cells, encode spatial information through frequency\u2010selective responses to direction\u2010dependent spectral features. Here, single\u2010unit recordings from the guinea pig CN revealed transient alterations by somatosensory and vestibular stimulation in fusiform cell spatial coding. Changes in fusiform cell spectral sensitivity correlated with multisensory modulation of ventral CN D\u2010stellate cell responses, which provide direct, wideband inhibition to fusiform cells. These results suggest that multisensory inputs contribute to spatial coding in DCN fusiform cells via an inhibitory interneuron, the D\u2010stellate cell. This early multisensory integration circuit likely confers important consequences on perceptual organization downstream.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp276280","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T05:27:42Z","timestamp":1533619662000},"page":"4537-4548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Multisensory activation of ventral cochlear nucleus D\u2010stellate cells modulates dorsal cochlear nucleus principal cell spatial coding"],"prefix":"10.1113","volume":"596","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2622-0576","authenticated-orcid":false,"given":"Calvin","family":"Wu","sequence":"first","affiliation":[{"name":"Kresge Hearing Research Institute Department of Otolaryngology University of Michigan  Ann Arbor MI 48109 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