{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:35:30Z","timestamp":1790217330837,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["14\/24294\u20106"],"award-info":[{"award-number":["14\/24294\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Dysfunction of post\u2010exercise cardiac autonomic control is associated with increased mortality risk in healthy adults and in patients with cardiorespiratory diseases.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The afferent mechanisms that regulate the post\u2010exercise cardiac autonomic control remain unclear.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We found that afferent signals from carotid chemoreceptors restrain the post\u2010exercise cardiac autonomic control in healthy adults and patients with pulmonary arterial hypertension (PAH).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Patients with PAH had higher carotid chemoreflex sensitivity, and the magnitude of carotid chemoreceptor restraint of autonomic control was greater in patients with PAH as compared to healthy adults.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results demonstrate that the carotid chemoreceptors contribute to the regulation of post\u2010exercise cardiac autonomic control, and suggest that the carotid chemoreceptors may be a potential target to treat post\u2010exercise cardiac autonomic dysfunction in patients with PAH.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Dysfunction of post\u2010exercise cardiac autonomic control predicts mortality, but its underlying mechanisms remain unclear. We tested whether carotid chemoreflex activity restrains post\u2010exercise cardiac autonomic control in healthy adults (HA), and whether such restraint is greater in patients with pulmonary arterial hypertension (PAH) who may have both altered carotid chemoreflex and altered post\u2010exercise cardiac autonomic control. Twenty non\u2010hypoxaemic patients with PAH and 13 age\u2010 and sex\u2010matched HA pedalled until 90% of peak work rate observed in a symptom\u2010limited ramp\u2010incremental exercise test. Recovery consisted of unloaded pedalling for 5\u00a0min followed by seated rest for 6\u00a0min. During recovery, subjects randomly inhaled either 100% O<jats:sub>2<\/jats:sub> (hyperoxia) to inhibit the carotid chemoreceptor activity, or 21% O<jats:sub>2<\/jats:sub> (normoxia) as control. Post\u2010exercise cardiac autonomic control was examined via heart rate (HR) recovery (HRR; HR change after 30, 60, 120 and 300\u00a0s of recovery, using linear and non\u2010linear regressions of HR decay) and HR variability (HRV; time and spectral domain analyses). As expected, the PAH group had higher carotid chemosensitivity and worse post\u2010exercise HRR and HRV than HA. Hyperoxia increased HRR at 30, 60 and 120\u00a0s and absolute spectral power HRV in both groups. Additionally, hyperoxia resulted in an accelerated linear HR decay and increased time domain HRV during active recovery only in the PAH group. In conclusion, the carotid chemoreceptors restrained recovery of cardiac autonomic control from exercise in HA and in patients with PAH, with the restraint greater for some autonomic indexes in patients with PAH.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp277190","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T07:26:09Z","timestamp":1547105169000},"page":"1347-1360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Carotid chemoreflex activity restrains post\u2010exercise cardiac autonomic control in healthy humans and in patients with pulmonary arterial hypertension"],"prefix":"10.1113","volume":"597","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9995-0035","authenticated-orcid":false,"given":"Marcelle","family":"Paula\u2010Ribeiro","sequence":"first","affiliation":[{"name":"Post\u2010graduate Program in Translational Medicine Department of Medicine Federal University of S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo SP Brazil"},{"name":"Pulmonary Vascular Group and Pulmonary Function and Clinical Exercise Physiology Unit Division of Respiratory Diseases Department of Medicine UNIFESP  S\u00e3o Paulo SP Brazil"},{"name":"Department of Physiology UNIFESP  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indyanara C.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Group and Pulmonary Function and Clinical Exercise Physiology Unit Division of Respiratory Diseases Department of Medicine UNIFESP  S\u00e3o Paulo SP Brazil"},{"name":"Department of Physiology UNIFESP  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane C.","family":"Aranda","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Group and Pulmonary Function and Clinical Exercise Physiology Unit Division of Respiratory Diseases Department of Medicine UNIFESP  S\u00e3o Paulo SP Brazil"},{"name":"Department of Physiology UNIFESP  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Group and Pulmonary Function and Clinical Exercise Physiology Unit Division of Respiratory Diseases Department of Medicine UNIFESP  S\u00e3o Paulo SP Brazil"},{"name":"Department of Physiology UNIFESP  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila M.","family":"Costa","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Group and Pulmonary Function and Clinical Exercise Physiology Unit Division of Respiratory Diseases Department of Medicine UNIFESP  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta P.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Group and Pulmonary Function and Clinical Exercise Physiology Unit Division of Respiratory Diseases Department of Medicine UNIFESP  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaquelina S.","family":"Ota\u2010Arakaki","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Group and Pulmonary Function and Clinical Exercise Physiology Unit Division of Respiratory Diseases Department of Medicine UNIFESP  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio L.","family":"Cravo","sequence":"additional","affiliation":[{"name":"Department of Physiology UNIFESP  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz E.","family":"Nery","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Group and Pulmonary Function and Clinical Exercise Physiology Unit Division of Respiratory Diseases Department of Medicine UNIFESP  S\u00e3o Paulo SP 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