{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:56:06Z","timestamp":1792648566779,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008713","name":"Diabetes Australia Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1045602"],"award-info":[{"award-number":["1045602"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003921","name":"Department of Health, Australian Government","doi-asserted-by":"publisher","award":["1045602"],"award-info":[{"award-number":["1045602"]}],"id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Fetal growth is dependent on effective placental nutrient transportation, which is regulated by mammalian target of rapamycin (mTOR) complex 1 modulation of nutrient transporter expression. These transporters are dysregulated in pregnancies affected by uteroplacental insufficiency and maternal obesity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Nutrient transporters and mTOR were altered in placentae of mothers born growth restricted compared to normal birth weight dams, with maternal diet\u2010 and fetal sex\u2010specific responses.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Exercise initiated during pregnancy downregulated mTOR protein expression, despite an increase in mTOR activation in male associated placentae, and reduced nutrient transporter gene abundance, which was also dependent on maternal diet and fetal sex.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Limited changes were characterized with exercise initiated before and continued throughout pregnancy in nutrient transporter and mTOR expression.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Maternal exercise during pregnancy differentially regulated mTOR and nutrient transporters in a diet\u2010 and sex\u2010specific manner, which likely aimed to improve late gestational placental growth and neonatal survival.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Adequate transplacental nutrient delivery is essential for fetoplacental development. Intrauterine growth restriction and maternal obesity independently alter placental nutrient transporter expression. Although exercise is beneficial for maternal health, limited studies have characterized how the timing of exercise initiation influences placental nutrient transport. Therefore, this study investigated the impact of maternal exercise on placental mechanistic target of rapamycin (mTOR) and nutrient transporter expression in growth restricted mothers and whether these outcomes were dependent on maternal diet or fetal sex. Uteroplacental insufficiency or sham surgery was induced on embryonic day (E) 18 in Wistar\u2013Kyoto rats. F1 offspring were fed a chow or high\u2010fat diet from weaning and at 16 weeks were randomly allocated to an exercise protocol: sedentary, exercised prior to and during pregnancy, or exercised during pregnancy only. Females were mated with normal males (20 weeks) and F2 placentae collected at E20. Exercise during pregnancy only, reduced mTOR protein expression in all groups and increased mTOR activation in male associated placentae. Exercise during pregnancy only, decreased the expression of amino acid transporters in a diet\u2010 and sex\u2010specific manner. Maternal growth restriction altered mTOR and system A amino acid transporter expression in a sex\u2010 and diet\u2010specific manner. These data highlight that maternal exercise initiated during pregnancy alters placental mTOR expression, which may directly regulate amino acid transporter expression, to a greater extent than exercise initiated prior to and continued during pregnancy, in a diet\u2010 and fetal sex\u2010dependent manner. These findings highlight that the timing of exercise initiation is important for optimal placental function.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp277227","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T06:03:10Z","timestamp":1549605790000},"page":"1905-1918","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Exercise initiated during pregnancy in rats born growth restricted alters placental mTOR and nutrient transporter expression"],"prefix":"10.1113","volume":"597","author":[{"given":"Yeukai T. 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