{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:14:16Z","timestamp":1782738856402,"version":"3.54.5"},"reference-count":79,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Cancer growth, cell proliferation and cachexia index can be attenuated by the beneficial programming effect of moderate exercise training, especially if it begins in adolescence.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Walker 256 tumour\u2010bearing rats who started exercise training during adolescence did not revert the basal low glycaemia and insulinaemia observed before tumour cell inoculation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The moderate exercise training improved glucose tolerance and peripheral insulin sensitivity only in rats exercised early in adolescence.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The chronic effects of our exercise protocol are be beneficial to prevent cancer cachexia and hold clear potential as a nonpharmacological therapy of insulin sensitization.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>We tested the hypothesis that moderate exercise training, performed early, starting during adolescence or later in life during adulthood, can inhibit tumour cell growth as a result of changes in biometric and metabolic markers. Male rats that were 30 and 70\u00a0days old performed a treadmill running protocol over 8\u00a0weeks for 3 days\u00a0week<jats:sup>\u20131<\/jats:sup>, 44 min\u00a0day<jats:sup>\u20131<\/jats:sup> and at 55\u201365% <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tjp13550-math-0001.png\" xlink:title=\"urn:x-wiley:00223751:media:tjp13550:tjp13550-math-0001\"\/>. After the end of training, a batch of rats was inoculated with Walker 256 carcinoma cells. At 15\u00a0days after carcinoma cell inoculation, the tumour was weighed and certain metabolic parameters were evaluated. The data demonstrated that physical performance was better in rats that started exercise training during adolescence according to the final workload and <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tjp13550-math-0002.png\" xlink:title=\"urn:x-wiley:00223751:media:tjp13550:tjp13550-math-0002\"\/>. Early or later moderate exercise training decreased the cachexia index, cell proliferation and tumour growth; however, the effects were more pronounced in rats that exercised during adolescence. Low glycaemia, insulinaemia and tissue insulin sensitivity was not reverted in Walker 256 tumour\u2010bearing rats who trained during adolescence. Cancer growth can be attenuated by the beneficial programming effect of moderate exercise training, especially if it begins during adolescence. In addition, improvement in glucose\u2013insulin homeostasis might be involved in this process.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp277645","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T09:06:23Z","timestamp":1560848783000},"page":"3905-3925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Moderate exercise training since adolescence reduces Walker 256 tumour growth in adult rats"],"prefix":"10.1113","volume":"597","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0502-6029","authenticated-orcid":false,"given":"Veridiana Mota","family":"Moreira","sequence":"first","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"},{"name":"Department of Physical Education State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Almeida","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudin\u00e9ia Conationi","family":"da Silva Franco","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Mello","family":"Gomes","sequence":"additional","affiliation":[{"name":"Biomedical Institute Federal University of Goi\u00e1s  Goi\u00e2nia GO Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesia","family":"Palma\u2010Rigo","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly Val\u00e9rio","family":"Prates","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-6386","authenticated-orcid":false,"given":"Laize Peron","family":"T\u00f3folo","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"},{"name":"Department of Physical Education State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananda","family":"Malta","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio Andrade","family":"Francisco","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-4493","authenticated-orcid":false,"given":"Audrei","family":"Pavanello","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Previate","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"da Silva Silveira","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane Aparecida","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Peixoto","family":"Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Praxedes","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Cristina Ianoni","family":"Matiusso","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Paulo Jacinto","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia Gama","family":"de Barros Machado","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thauany","family":"Fabbri Cor\u00e1","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriane","family":"Gongora","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Eduardo","family":"Cardozo","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"},{"name":"Department of Physical Education State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9956-2078","authenticated-orcid":false,"given":"Paulo Henrique Olivieri","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"},{"name":"Department of Physical Education State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan","family":"Venci","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Vieira","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Program of Physical Education Catholic University of Bras\u00edlia  \u00c1guas Claras DF Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-9348","authenticated-orcid":false,"given":"J\u00falio Cezar","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences Federal University of Mato Grosso  Sinop MT Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0978-7949","authenticated-orcid":false,"given":"Rosiane Aparecida","family":"Miranda","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Endocrinology Carlos Chagas Filho Biophysis Institute Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helenir Medri","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Physiology State University of Londrina  Londrina PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Miksza","sequence":"additional","affiliation":[{"name":"Department of Physiology State University of Londrina  Londrina PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Delmar","family":"da Costa Lima","sequence":"additional","affiliation":[{"name":"Superior School of Physical Education and Physical Therapy of Goi\u00e1s State State University of Goi\u00e1s  Goi\u00e2nia GO Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialba Avezum Alves","family":"de Castro\u2010Prado","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Genetics and Mutagenesis Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Department of Physical Education State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Cezar","family":"de Freitas Mathias","sequence":"additional","affiliation":[{"name":"Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology, State University of Maring\u00e1  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200201000-00015"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.11.029"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/789174"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3181\/0704-RM-93"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0844(200012)18:4<249::AID-CBF879>3.0.CO;2-2"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2011.11.014"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0972-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.05.001"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv040"},{"key":"e_1_2_5_11_1","first-page":"257","article-title":"Endurance training activates AMP\u2010activated protein kinase, increases expression of uncoupling protein 2 and reduces insulin secretion from rat pancreatic islets","volume":"208","author":"Calegari VC","year":"2011","journal-title":"J Endocrinol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.1.161S"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477117"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-5207-7"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0408"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.10.002"},{"key":"e_1_2_5_17_1","first-page":"1","article-title":"Acute high intensity interval exercise reduces colon cancer cell growth","author":"Devin JL","year":"2019","journal-title":"J Physiol"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.10.021"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/601434"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366390"},{"key":"e_1_2_5_22_1","first-page":"1","article-title":"Infusion of high concentration of lactate in perfused liver, simulating in vivo hyperlactatemia, prevents the reduction of gluconeogenesis in Walker\u2010256 tumor\u2010bearing rats","author":"Frasson\u2010Uemura IG","year":"2019","journal-title":"J Cell Biochem"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2015.990569"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354439"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0096-0"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270818"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000225631"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201601151R"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089446"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.5327"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.6.583"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-155"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-005-1138-0"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/28.3.276"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1041914"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2006.12.006"},{"key":"e_1_2_5_37_1","first-page":"2","article-title":"Changes in the GLUT4 expression by acute exercise, exercise training and detraining in experimental models","volume":"10","author":"Lehnen A","year":"2012","journal-title":"J Diabetes Metab S"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-9-67"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1139\/h11-047"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-008-0849-9"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2013-0554"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1495"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-8-60"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5291.1507"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2016.10.020"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)44037-5"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(13)71077-6"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.11.s1.s86"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607187011003219"},{"key":"e_1_2_5_50_1","first-page":"4925","article-title":"Insulin reversal of cancer cachexia in rats","volume":"45","author":"Moley JF","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00465"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.517"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7153610"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2016.3"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.82297"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.4172\/2157-7013.1000211"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/1550-2783-11-25"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-6-38"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5087.5"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4068-3"},{"key":"e_1_2_5_61_1","first-page":"1","article-title":"Role of physical activity in onset, prevention and treatment of human neoplasms","author":"Scimeca M","year":"2019","journal-title":"Future Oncology"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-009-9263-2"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00257788"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0358"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2008"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00170"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200131010-00001"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00353.2004"},{"key":"e_1_2_5_70_1","first-page":"1","article-title":"Early treatment with metformin induces resistance against tumor growth in adult rats","author":"Trombini AB","year":"2015","journal-title":"Cancer Biol Ther"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22203"},{"issue":"2","key":"e_1_2_5_72_1","first-page":"S94","article-title":"Weight control and physical activity in cancer prevention: international evaluation of the evidence","volume":"11","author":"Vainio H","year":"2002","journal-title":"Eur J Cancer Prev"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1689-1"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3220"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0251"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200308000-00007"},{"key":"e_1_2_5_77_1","first-page":"426","article-title":"Effects of free fatty acids on the growth of normal and neoplastic rat mammary epithelial cells","volume":"39","author":"Wicha MS","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.3.H1301"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605642"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3754"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FJP277645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP277645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/JP277645","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP277645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T12:35:10Z","timestamp":1693917310000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP277645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,18]]},"references-count":79,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1113\/JP277645"],"URL":"https:\/\/doi.org\/10.1113\/jp277645","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,18]]},"assertion":[{"value":"2019-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}