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Fructose is primarily metabolised by the liver in humans, and increases rates of hepatic <jats:italic>de novo<\/jats:italic> lipogenesis. Fructose increases hepatic <jats:italic>de novo<\/jats:italic> lipogenesis via numerous mechanisms: by altering transcriptional and allosteric regulation, interfering with cellular energy sensing, and disrupting the balance between lipid synthesis and lipid oxidation. Hepatic <jats:italic>de novo<\/jats:italic> lipogenesis is also upregulated by the inability to synthesise glycogen, either when storage is inhibited in knock\u2010down animal models or storage is saturated in glycogen storage disease. Considering that fructose has the capacity to upregulate hepatic glycogen storage, and replenish these stores more readily following glycogen depleting exercise, the idea that hepatic glycogen storage and hepatic <jats:italic>de novo<\/jats:italic> lipogenesis are linked is an attractive prospect. 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Since physical activity potently modulates glycogen metabolism, this provides a rationale for considering nutrient\u2013physical activity interactions in metabolic health.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp13513-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1113\/jp277767","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T04:47:45Z","timestamp":1554526065000},"page":"3573-3585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Fructose and metabolic health: governed by hepatic glycogen status?"],"prefix":"10.1113","volume":"597","author":[{"given":"Aaron","family":"Hengist","sequence":"first","affiliation":[{"name":"Department for Health University of Bath  Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9029-3390","authenticated-orcid":false,"given":"Francoise","family":"Koumanov","sequence":"additional","affiliation":[{"name":"Department for Health University of Bath  Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9939-0074","authenticated-orcid":false,"given":"Javier T.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department for Health University of Bath  Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S000711459800107X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/48.2.240"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)95917-X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0125-z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00144.2005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31816c9013"},{"key":"e_1_2_8_8_1","unstructured":"BarberS(2017).The Soft Drinks Industry Levy. 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