{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:23:27Z","timestamp":1787016207096,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:00:00Z","timestamp":1555632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Obstructive sleep apnoea (OSA) is a chronic condition characterized by intermittent hypoxia that induces oxidative stress and inflammation leading to cardiovascular disease.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Women can develop OSA during late pregnancy, which is associated with adverse maternal and fetal outcomes. However, the effects of OSA throughout pregnancy on fetoplacental outcomes are unknown.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Using a mouse model of intermittent hypoxia, we evaluated main uterine artery function, spiral artery remodelling, circulating angiogenic and anti\u2010angiogenic factors, and placental hypoxia and oxidative stress at gestational day 14.5 in pregnant mice.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Gestational intermittent hypoxia increased placental weight but decreased fetal weight, impaired uterine artery function, increased circulating angiogenic and anti\u2010angiogenic factors, and induced placental hypoxia and oxidative stress, but had no impact on spiral artery remodelling.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our results suggest that pregnant women experiencing OSA during pregnancy could be at risk of maternal and fetal complications.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Obstructive sleep apnoea (OSA) is characterized by chronic intermittent hypoxia (IH) and is associated with increased inflammation, oxidative stress and endothelial dysfunction. OSA is a common sleep disorder and remains under\u2010diagnosed; it can increase the risk of adverse maternal and fetal outcomes in pregnant women. We investigated the effects of gestational IH (GIH) on uterine artery function, spiral artery remodelling and placental circulating angiogenic and anti\u2010angiogenic factors in pregnant female mice. WT C57BL\/6\u00a0mice (8\u00a0weeks) were exposed to either GIH (\n                      <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tjp13504-math-0001.png\" xlink:title=\"urn:x-wiley:00223751:media:tjp13504:tjp13504-math-0001\"\/>\n                      12%) or intermittent air (\n                      <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tjp13504-math-0002.png\" xlink:title=\"urn:x-wiley:00223751:media:tjp13504:tjp13504-math-0002\"\/>\n                      21%) for 14.5\u00a0days of gestation. Exposure to GIH reduced fetal weight but increased placental weight. GIH dams had higher plasma levels of oxidative stress (8\u2010isoprostane) and inflammatory markers (tumour necrosis factor\u2010\u03b1). GIH significantly reduced uterine artery function as indicated by reduced endothelium\u2010dependent vasodilatation and enhanced vasoconstriction. Plasma levels of placental angiogenic and anti\u2010angiogenic markers (soluble fms\u2010like tyrosine kinase\u20101, soluble endoglin, angiogenic placental growth factor\u20102 and vascular endothelial growth factor) were higher in pregnant mice exposed to GIH. There was no evidence of impaired spiral artery remodelling based on immunostaining with \u03b1\u2010smooth muscle actin and cytokeratin\u20107, and also by measurements of lumen area. Immunostaining for markers of hypoxia (pimonidazole) and oxidative stress (4\u2010hydroxynonenal) were higher in mice exposed to GIH. Our data show that GIH adversely affects uterine vascular function and may be a mechanism by which gestational OSA leads to adverse maternal and fetal outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp277775","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T17:16:54Z","timestamp":1555694214000},"page":"2639-2650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Intermittent hypoxia impairs uterine artery function in pregnant mice"],"prefix":"10.1113","volume":"597","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7073-741X","authenticated-orcid":false,"given":"Mohammad","family":"Badran","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Pharmacology and Therapeutics University of British Columbia  Vancouver 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